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Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction
[Image: see text] An iridium-catalyzed, reductive alkylation of abundant tertiary lactams and amides using 1–2 mol % of Vaska’s complex (IrCl(CO)(PPh(3))(2)), tetramethyldisiloxane (TMDS), and difluoro-Reformatsky reagents (BrZnCF(2)R) for the general synthesis of medicinally relevant α-difluoroalky...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082613/ https://www.ncbi.nlm.nih.gov/pubmed/35258311 http://dx.doi.org/10.1021/acs.orglett.2c00438 |