Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET–rearranged thyroid cancer

Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in treating patients with diverse tumor types harbori...

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Detalles Bibliográficos
Autores principales: Raman, Renuka, Villefranc, Jacques A., Ullmann, Timothy M., Thiesmeyer, Jessica, Anelli, Viviana, Yao, Jun, Hurley, James R., Pauli, Chantal, Bareja, Rohan, Wha Eng, Kenneth, Dorsaint, Princesca, Wilkes, David C., Beg, Shaham, Kudman, Sarah, Shaw, Reid, Churchill, Michael, Ahmed, Adnan, Keefer, Laurel, Misner, Ian, Nichol, Donna, Gumpeni, Naveen, Scognamiglio, Theresa, Rubin, Mark A., Grandori, Carla, Solomon, James Patrick, Song, Wei, Mosquera, Juan Miguel, Dephoure, Noah, Sboner, Andrea, Elemento, Olivier, Houvras, Yariv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082625/
https://www.ncbi.nlm.nih.gov/pubmed/35510953
http://dx.doi.org/10.1084/jem.20210390

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