Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia

Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SAR...

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Detalles Bibliográficos
Autores principales: Sorek, Matan, Meshorer, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082776/
https://www.ncbi.nlm.nih.gov/pubmed/35537401
http://dx.doi.org/10.1016/j.devcel.2022.04.015
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author Sorek, Matan
Meshorer, Eran
author_facet Sorek, Matan
Meshorer, Eran
author_sort Sorek, Matan
collection PubMed
description Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance.
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spelling pubmed-90827762022-05-09 Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia Sorek, Matan Meshorer, Eran Dev Cell Spotlight Anosmia, or loss of smell, is strongly associated with SARS-CoV-2 infection in humans, but the underlying mechanism remains obscure. In a recent Cell study, Zazhytska et al. (2022) report non-cell-autonomous disruption of long-range genomic interactions of olfactory receptor genes in response to SARS-CoV-2 infection, and these interactions remain disrupted long after virus clearance. Elsevier Inc. 2022-05-09 2022-05-09 /pmc/articles/PMC9082776/ /pubmed/35537401 http://dx.doi.org/10.1016/j.devcel.2022.04.015 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Spotlight
Sorek, Matan
Meshorer, Eran
Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title_full Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title_fullStr Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title_full_unstemmed Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title_short Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia
title_sort can’t smell the virus: sars-cov-2, chromatin organization, and anosmia
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082776/
https://www.ncbi.nlm.nih.gov/pubmed/35537401
http://dx.doi.org/10.1016/j.devcel.2022.04.015
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