A DOX-loaded polymer micelle for effectively inhibiting cancer cells

A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have...

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Detalles Bibliográficos
Autores principales: Feng, Huayang, Chu, Dandan, Li, Zhanrong, Guo, Zhihua, Jin, Lin, Fan, Bingbing, Zhang, Junjie, Li, Jingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082780/
https://www.ncbi.nlm.nih.gov/pubmed/35541975
http://dx.doi.org/10.1039/c8ra04089c
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author Feng, Huayang
Chu, Dandan
Li, Zhanrong
Guo, Zhihua
Jin, Lin
Fan, Bingbing
Zhang, Junjie
Li, Jingguo
author_facet Feng, Huayang
Chu, Dandan
Li, Zhanrong
Guo, Zhihua
Jin, Lin
Fan, Bingbing
Zhang, Junjie
Li, Jingguo
author_sort Feng, Huayang
collection PubMed
description A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment.
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spelling pubmed-90827802022-05-09 A DOX-loaded polymer micelle for effectively inhibiting cancer cells Feng, Huayang Chu, Dandan Li, Zhanrong Guo, Zhihua Jin, Lin Fan, Bingbing Zhang, Junjie Li, Jingguo RSC Adv Chemistry A novel triblock polymer is synthesized and self-assembled with doxorubicin to form DOX-loaded micelles. The synthetic process involves the ring-opening polymerization, carboxylation and amidation reactions, and the structures are characterized. The drug release test indicated that the micelles have the ability to control the release of drugs. The cell uptake results indicated that the DOX-loaded micelles could enter cancer cells easily, and the cytotoxicity and apoptosis test confirmed that DOX-loaded micelles have a strong killing effect on tumor cells, while the blank micelles do not have cytotoxicity. Therefore, the novel polymer micelles are a promising carrier for delivery of anticancer drugs to enhance cancer treatment. The Royal Society of Chemistry 2018-07-19 /pmc/articles/PMC9082780/ /pubmed/35541975 http://dx.doi.org/10.1039/c8ra04089c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Feng, Huayang
Chu, Dandan
Li, Zhanrong
Guo, Zhihua
Jin, Lin
Fan, Bingbing
Zhang, Junjie
Li, Jingguo
A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title_full A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title_fullStr A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title_full_unstemmed A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title_short A DOX-loaded polymer micelle for effectively inhibiting cancer cells
title_sort dox-loaded polymer micelle for effectively inhibiting cancer cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082780/
https://www.ncbi.nlm.nih.gov/pubmed/35541975
http://dx.doi.org/10.1039/c8ra04089c
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