Non-AUG translation initiation in mammals

Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure o...

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Autores principales: Andreev, Dmitry E., Loughran, Gary, Fedorova, Alla D., Mikhaylova, Maria S., Shatsky, Ivan N., Baranov, Pavel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082881/
https://www.ncbi.nlm.nih.gov/pubmed/35534899
http://dx.doi.org/10.1186/s13059-022-02674-2
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author Andreev, Dmitry E.
Loughran, Gary
Fedorova, Alla D.
Mikhaylova, Maria S.
Shatsky, Ivan N.
Baranov, Pavel V.
author_facet Andreev, Dmitry E.
Loughran, Gary
Fedorova, Alla D.
Mikhaylova, Maria S.
Shatsky, Ivan N.
Baranov, Pavel V.
author_sort Andreev, Dmitry E.
collection PubMed
description Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-022-02674-2.
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spelling pubmed-90828812022-05-10 Non-AUG translation initiation in mammals Andreev, Dmitry E. Loughran, Gary Fedorova, Alla D. Mikhaylova, Maria S. Shatsky, Ivan N. Baranov, Pavel V. Genome Biol Review Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-022-02674-2. BioMed Central 2022-05-09 /pmc/articles/PMC9082881/ /pubmed/35534899 http://dx.doi.org/10.1186/s13059-022-02674-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Andreev, Dmitry E.
Loughran, Gary
Fedorova, Alla D.
Mikhaylova, Maria S.
Shatsky, Ivan N.
Baranov, Pavel V.
Non-AUG translation initiation in mammals
title Non-AUG translation initiation in mammals
title_full Non-AUG translation initiation in mammals
title_fullStr Non-AUG translation initiation in mammals
title_full_unstemmed Non-AUG translation initiation in mammals
title_short Non-AUG translation initiation in mammals
title_sort non-aug translation initiation in mammals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082881/
https://www.ncbi.nlm.nih.gov/pubmed/35534899
http://dx.doi.org/10.1186/s13059-022-02674-2
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