A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation

The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potential genetic contributing factors. The complex aetiol...

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Detalles Bibliográficos
Autores principales: Winter, Matthew J., Ono, Yosuke, Ball, Jonathan S., Walentinsson, Anna, Michaelsson, Erik, Tochwin, Anna, Scholpp, Steffen, Tyler, Charles R., Rees, Steve, Hetheridge, Malcolm J, Bohlooly-Y, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082939/
https://www.ncbi.nlm.nih.gov/pubmed/35548346
http://dx.doi.org/10.3389/fphar.2022.827686

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