Cargando…

Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report

Influenza-associated encephalopathy (IAE) is most frequently observed in young children, but less reported in adults. Diagnosis of IAE is difficult, as clinical presentations vary significantly and the influenza virus is rarely detected in cerebrospinal fluid (CSF). Herein, we described the case of...

Descripción completa

Detalles Bibliográficos
Autores principales: Dou, Yu-chao, Li, Yu-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082942/
https://www.ncbi.nlm.nih.gov/pubmed/35547385
http://dx.doi.org/10.3389/fneur.2022.874078
_version_ 1784703312404152320
author Dou, Yu-chao
Li, Yu-qing
author_facet Dou, Yu-chao
Li, Yu-qing
author_sort Dou, Yu-chao
collection PubMed
description Influenza-associated encephalopathy (IAE) is most frequently observed in young children, but less reported in adults. Diagnosis of IAE is difficult, as clinical presentations vary significantly and the influenza virus is rarely detected in cerebrospinal fluid (CSF). Herein, we described the case of an older adult presenting with acute meningoencephalitis due to an influenza A (H3N2) infection and the influenza A (H3N2) RNA is detected in cerebrospinal fluid. To the best of our knowledge, this is infrequently reported in the literature. We emphasize that, in adults presenting with acute viral encephalitis, clinicians should consider an influenza infection as part of the differential diagnosis and that metagenomic next-generation sequencing of CSF for IAE may help establish an accurate diagnosis. It must be emphasized that the administration of steroids in a timely manner following the onset of symptoms may yield a better outcome in patients.
format Online
Article
Text
id pubmed-9082942
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90829422022-05-10 Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report Dou, Yu-chao Li, Yu-qing Front Neurol Neurology Influenza-associated encephalopathy (IAE) is most frequently observed in young children, but less reported in adults. Diagnosis of IAE is difficult, as clinical presentations vary significantly and the influenza virus is rarely detected in cerebrospinal fluid (CSF). Herein, we described the case of an older adult presenting with acute meningoencephalitis due to an influenza A (H3N2) infection and the influenza A (H3N2) RNA is detected in cerebrospinal fluid. To the best of our knowledge, this is infrequently reported in the literature. We emphasize that, in adults presenting with acute viral encephalitis, clinicians should consider an influenza infection as part of the differential diagnosis and that metagenomic next-generation sequencing of CSF for IAE may help establish an accurate diagnosis. It must be emphasized that the administration of steroids in a timely manner following the onset of symptoms may yield a better outcome in patients. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9082942/ /pubmed/35547385 http://dx.doi.org/10.3389/fneur.2022.874078 Text en Copyright © 2022 Dou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Dou, Yu-chao
Li, Yu-qing
Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title_full Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title_fullStr Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title_full_unstemmed Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title_short Influenza A H3N2-Associated Meningoencephalitis in an Older Adult With Viral RNA in Cerebrospinal Fluid: Case Report
title_sort influenza a h3n2-associated meningoencephalitis in an older adult with viral rna in cerebrospinal fluid: case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082942/
https://www.ncbi.nlm.nih.gov/pubmed/35547385
http://dx.doi.org/10.3389/fneur.2022.874078
work_keys_str_mv AT douyuchao influenzaah3n2associatedmeningoencephalitisinanolderadultwithviralrnaincerebrospinalfluidcasereport
AT liyuqing influenzaah3n2associatedmeningoencephalitisinanolderadultwithviralrnaincerebrospinalfluidcasereport