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Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite
A highly conductive electrochemical sensor was constructed for the simultaneous electrochemical determination of levodopa and piroxicam by modification of a glassy carbon electrode with a ZnO–Pd/CNT nanocomposite (GCE/ZnO–Pd/CNTs). The ZnO–Pd/CNT nanocomposite was synthesized by the sol–gel procedur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083090/ https://www.ncbi.nlm.nih.gov/pubmed/35541045 http://dx.doi.org/10.1039/c8ra03460e |
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author | Karimi-Maleh, Hassan Sheikhshoaie, Iran Samadzadeh, Ali |
author_facet | Karimi-Maleh, Hassan Sheikhshoaie, Iran Samadzadeh, Ali |
author_sort | Karimi-Maleh, Hassan |
collection | PubMed |
description | A highly conductive electrochemical sensor was constructed for the simultaneous electrochemical determination of levodopa and piroxicam by modification of a glassy carbon electrode with a ZnO–Pd/CNT nanocomposite (GCE/ZnO–Pd/CNTs). The ZnO–Pd/CNT nanocomposite was synthesized by the sol–gel procedure and was characterized by EDAX, MAP and SEM. The sensor was shown to improve the oxidation signal of levodopa and piroxicam by ∼70.2-fold and ∼41.5-fold, respectively. This marks the first time that the electrochemical behavior of levodopa and piroxicam have been investigated at the surface of GCE/ZnO–Pd/CNTs. The voltammogram showed a quasi-reversible signal and an irreversible redox signal for electro-oxidation of levodopa and piroxicam, respectively. The GCE/ZnO–Pd/CNTs showed a linear dynamic range of 0.6 to 100.0 μM (at a potential of ∼180 mV) and 0.1 to 90 μM (at a potential of ∼480 mV) with detection limits of 0.08 and 0.04 μM for the determination of levodopa and piroxicam, respectively. GCE/ZnO–Pd/CNTs were then applied for the determination of levodopa and piroxicam in real samples. |
format | Online Article Text |
id | pubmed-9083090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90830902022-05-09 Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite Karimi-Maleh, Hassan Sheikhshoaie, Iran Samadzadeh, Ali RSC Adv Chemistry A highly conductive electrochemical sensor was constructed for the simultaneous electrochemical determination of levodopa and piroxicam by modification of a glassy carbon electrode with a ZnO–Pd/CNT nanocomposite (GCE/ZnO–Pd/CNTs). The ZnO–Pd/CNT nanocomposite was synthesized by the sol–gel procedure and was characterized by EDAX, MAP and SEM. The sensor was shown to improve the oxidation signal of levodopa and piroxicam by ∼70.2-fold and ∼41.5-fold, respectively. This marks the first time that the electrochemical behavior of levodopa and piroxicam have been investigated at the surface of GCE/ZnO–Pd/CNTs. The voltammogram showed a quasi-reversible signal and an irreversible redox signal for electro-oxidation of levodopa and piroxicam, respectively. The GCE/ZnO–Pd/CNTs showed a linear dynamic range of 0.6 to 100.0 μM (at a potential of ∼180 mV) and 0.1 to 90 μM (at a potential of ∼480 mV) with detection limits of 0.08 and 0.04 μM for the determination of levodopa and piroxicam, respectively. GCE/ZnO–Pd/CNTs were then applied for the determination of levodopa and piroxicam in real samples. The Royal Society of Chemistry 2018-07-26 /pmc/articles/PMC9083090/ /pubmed/35541045 http://dx.doi.org/10.1039/c8ra03460e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Karimi-Maleh, Hassan Sheikhshoaie, Iran Samadzadeh, Ali Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title | Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title_full | Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title_fullStr | Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title_full_unstemmed | Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title_short | Simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a ZnO–Pd/CNT nanocomposite |
title_sort | simultaneous electrochemical determination of levodopa and piroxicam using a glassy carbon electrode modified with a zno–pd/cnt nanocomposite |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083090/ https://www.ncbi.nlm.nih.gov/pubmed/35541045 http://dx.doi.org/10.1039/c8ra03460e |
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