Cargando…

Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease

Emerging evidence suggests that patients with Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate whether pathological changes associated with neuronal death and cognitive dysfunction also occur in peripheral motor neurons and muscle as a function of age, we used the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Hongyang, Bhaskaran, Shylesh, Piekarz, Katarzyna M., Ranjit, Rojina, Bian, Jan, Kneis, Parker, Ellis, Aubrey, Bhandari, Suyesha, Rice, Heather C., Van Remmen, Holly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083113/ https://www.ncbi.nlm.nih.gov/pubmed/35547624 http://dx.doi.org/10.3389/fnagi.2022.876816

Ejemplares similares

Age-related changes in core body temperature and activity in triple-transgenic Alzheimer’s disease (3xTgAD) mice
por: Knight, Elysse M., et al.
Publicado: (2013)

Maternal High-Fat Diet Worsens Memory Deficits in the Triple-Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease
por: Martin, Sarah A. L., et al.
Publicado: (2014)

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology()
por: Knight, Elysse M., et al.
Publicado: (2014)

Increased Hippocampal Excitability in the 3xTgAD Mouse Model for Alzheimer's Disease In Vivo
por: Davis, Katherine E., et al.
Publicado: (2014)

Restoration of Sarcoplasmic Reticulum Ca(2+) ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
por: Qaisar, Rizwan, et al.
Publicado: (2020)

Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice
por: Wei, Zhang, et al.
Publicado: (2017)

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness
por: Qaisar, Rizwan, et al.
Publicado: (2018)

Acoustic Stimulation Improves Memory and Reverses the Contribution of Chronic Sleep Deprivation to Pathology in 3xTgAD Mice
por: Liu, Shunjie, et al.
Publicado: (2022)

Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia
por: Ahn, Bumsoo, et al.
Publicado: (2022)

iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease
por: Martin, Bronwen, et al.
Publicado: (2008)

Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer’s disease mice
por: Jew, Katrina, et al.
Publicado: (2019)

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia
por: Xu, Hongyang, et al.
Publicado: (2021)

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
por: Lauritzen, Inger, et al.
Publicado: (2013)

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model
por: Gabbita, S. Prasad, et al.
Publicado: (2015)

Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer’s Disease
por: McNerney, M. Windy, et al.
Publicado: (2022)

Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy
por: Ahn, Bumsoo, et al.
Publicado: (2019)

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
por: Qaisar, Rizwan, et al.
Publicado: (2018)

Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection
por: Montacute, Rebecca, et al.
Publicado: (2017)

Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia
por: Ranjit, Rojina, et al.
Publicado: (2022)

Cancer cachexia in a mouse model of oxidative stress
por: Brown, Jacob L., et al.
Publicado: (2020)

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)
por: Salobrar-García, Elena, et al.
Publicado: (2020)

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
por: Ahn, Bumsoo, et al.
Publicado: (2019)

Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation
por: Pharaoh, Gavin, et al.
Publicado: (2021)

Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia
por: Pharaoh, Gavin, et al.
Publicado: (2020)

Cognitive heterogeneity reveals molecular signatures of age-related impairment
por: Logan, Sreemathi, et al.
Publicado: (2023)

A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
por: Deepa, Sathyaseelan S., et al.
Publicado: (2017)

Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
por: Pharaoh, Gavin, et al.
Publicado: (2019)

Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
por: Bhaskaran, Shylesh, et al.
Publicado: (2020)

Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer’s Disease TgF-344 AD
por: Proskauer Pena, Stephanie L., et al.
Publicado: (2021)

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats
por: Daianu, Madelaine, et al.
Publicado: (2015)

Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer’s Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity
por: González-Luna, Irma Angélica, et al.
Publicado: (2021)

The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
por: Xu, Hongyang, et al.
Publicado: (2021)

Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
por: Chaney, Aisling M, et al.
Publicado: (2021)

BAC TG-EMBED: one-step method for high-level, copy-number-dependent, position-independent transgene expression
por: Bian, Qian, et al.
Publicado: (2010)

Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer’s disease
por: Kloskowska, Ewa, et al.
Publicado: (2010)

Late neurodegeneration in the Tau transgenic mouse model rTg4510
por: Helboe, Lone, et al.
Publicado: (2013)

Adult neurogenic deficits in HIV-1 Tg26 transgenic mice
por: Putatunda, Raj, et al.
Publicado: (2018)

Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation
por: Xu, Hongyang, et al.
Publicado: (2022)

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis
por: Bhaskaran, Shylesh, et al.
Publicado: (2022)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease
por: Mitrano, Darlene A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5ls06l95kaf8g4q546sef71dqh