Computational Insights of Unfolding of N-Terminal Domain of TDP-43 Reveal the Conformational Heterogeneity in the Unfolding Pathway

TDP-43 proteinopathies is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The N-terminal domain of TDP-43 (NTD) is important to both TDP-43 physiology and TDP-43 proteinopathy. However, its folding and dimerization process is st...

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Detalles Bibliográficos
Autores principales: Li, Ruiting, Singh, Ruhar, Kashav, Tara, Yang, ChunMin, Sharma, Ravi Datta, Lynn, Andrew M., Prasad, Rajendra, Prakash, Amresh, Kumar, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083116/
https://www.ncbi.nlm.nih.gov/pubmed/35548668
http://dx.doi.org/10.3389/fnmol.2022.822863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083116/
https://www.ncbi.nlm.nih.gov/pubmed/35548668
http://dx.doi.org/10.3389/fnmol.2022.822863

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