Cargando…
Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083129/ https://www.ncbi.nlm.nih.gov/pubmed/35541040 http://dx.doi.org/10.1039/c8ra05322g |
_version_ | 1784703355024572416 |
---|---|
author | Yan, Xi-Tao An, Zhen Tang, Dan Peng, Guang-Rui Cao, Chen-Yu Xu, Yuan-Zhen Li, Chun-Huan Liu, Pei-Liang Jiang, Zai-Min Gao, Jin-Ming |
author_facet | Yan, Xi-Tao An, Zhen Tang, Dan Peng, Guang-Rui Cao, Chen-Yu Xu, Yuan-Zhen Li, Chun-Huan Liu, Pei-Liang Jiang, Zai-Min Gao, Jin-Ming |
author_sort | Yan, Xi-Tao |
collection | PubMed |
description | Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as well as chemical derivatization. This is the first report of the identification of biphenyl ether glycosides as plant metabolites and their possible biosynthetic pathway is proposed. Except for 3, the new phenolic metabolites exhibited significant neurotrophic activities to enhance nerve growth factor-induced neurite outgrowth in PC12 cells. In addition, the anti-neuroinflammatory and antioxidant activities of compounds 1–15 were preliminarily evaluated in vitro. |
format | Online Article Text |
id | pubmed-9083129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90831292022-05-09 Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity Yan, Xi-Tao An, Zhen Tang, Dan Peng, Guang-Rui Cao, Chen-Yu Xu, Yuan-Zhen Li, Chun-Huan Liu, Pei-Liang Jiang, Zai-Min Gao, Jin-Ming RSC Adv Chemistry Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as well as chemical derivatization. This is the first report of the identification of biphenyl ether glycosides as plant metabolites and their possible biosynthetic pathway is proposed. Except for 3, the new phenolic metabolites exhibited significant neurotrophic activities to enhance nerve growth factor-induced neurite outgrowth in PC12 cells. In addition, the anti-neuroinflammatory and antioxidant activities of compounds 1–15 were preliminarily evaluated in vitro. The Royal Society of Chemistry 2018-07-25 /pmc/articles/PMC9083129/ /pubmed/35541040 http://dx.doi.org/10.1039/c8ra05322g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Yan, Xi-Tao An, Zhen Tang, Dan Peng, Guang-Rui Cao, Chen-Yu Xu, Yuan-Zhen Li, Chun-Huan Liu, Pei-Liang Jiang, Zai-Min Gao, Jin-Ming Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title | Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title_full | Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title_fullStr | Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title_full_unstemmed | Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title_short | Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity |
title_sort | hyperelatosides a–e, biphenyl ether glycosides from hypericum elatoides, with neurotrophic activity |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083129/ https://www.ncbi.nlm.nih.gov/pubmed/35541040 http://dx.doi.org/10.1039/c8ra05322g |
work_keys_str_mv | AT yanxitao hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT anzhen hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT tangdan hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT pengguangrui hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT caochenyu hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT xuyuanzhen hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT lichunhuan hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT liupeiliang hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT jiangzaimin hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity AT gaojinming hyperelatosidesaebiphenyletherglycosidesfromhypericumelatoideswithneurotrophicactivity |