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Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity

Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as...

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Autores principales: Yan, Xi-Tao, An, Zhen, Tang, Dan, Peng, Guang-Rui, Cao, Chen-Yu, Xu, Yuan-Zhen, Li, Chun-Huan, Liu, Pei-Liang, Jiang, Zai-Min, Gao, Jin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083129/
https://www.ncbi.nlm.nih.gov/pubmed/35541040
http://dx.doi.org/10.1039/c8ra05322g
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author Yan, Xi-Tao
An, Zhen
Tang, Dan
Peng, Guang-Rui
Cao, Chen-Yu
Xu, Yuan-Zhen
Li, Chun-Huan
Liu, Pei-Liang
Jiang, Zai-Min
Gao, Jin-Ming
author_facet Yan, Xi-Tao
An, Zhen
Tang, Dan
Peng, Guang-Rui
Cao, Chen-Yu
Xu, Yuan-Zhen
Li, Chun-Huan
Liu, Pei-Liang
Jiang, Zai-Min
Gao, Jin-Ming
author_sort Yan, Xi-Tao
collection PubMed
description Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as well as chemical derivatization. This is the first report of the identification of biphenyl ether glycosides as plant metabolites and their possible biosynthetic pathway is proposed. Except for 3, the new phenolic metabolites exhibited significant neurotrophic activities to enhance nerve growth factor-induced neurite outgrowth in PC12 cells. In addition, the anti-neuroinflammatory and antioxidant activities of compounds 1–15 were preliminarily evaluated in vitro.
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spelling pubmed-90831292022-05-09 Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity Yan, Xi-Tao An, Zhen Tang, Dan Peng, Guang-Rui Cao, Chen-Yu Xu, Yuan-Zhen Li, Chun-Huan Liu, Pei-Liang Jiang, Zai-Min Gao, Jin-Ming RSC Adv Chemistry Five new biphenyl ether glycosides, hyperelatosides A–E (1–5), one new benzoate glycoside, hyperelatoside F (6), along with nine known phenolic compounds (7–15), were isolated from the aerial parts of Hypericum elatoides. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS, as well as chemical derivatization. This is the first report of the identification of biphenyl ether glycosides as plant metabolites and their possible biosynthetic pathway is proposed. Except for 3, the new phenolic metabolites exhibited significant neurotrophic activities to enhance nerve growth factor-induced neurite outgrowth in PC12 cells. In addition, the anti-neuroinflammatory and antioxidant activities of compounds 1–15 were preliminarily evaluated in vitro. The Royal Society of Chemistry 2018-07-25 /pmc/articles/PMC9083129/ /pubmed/35541040 http://dx.doi.org/10.1039/c8ra05322g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yan, Xi-Tao
An, Zhen
Tang, Dan
Peng, Guang-Rui
Cao, Chen-Yu
Xu, Yuan-Zhen
Li, Chun-Huan
Liu, Pei-Liang
Jiang, Zai-Min
Gao, Jin-Ming
Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title_full Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title_fullStr Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title_full_unstemmed Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title_short Hyperelatosides A–E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity
title_sort hyperelatosides a–e, biphenyl ether glycosides from hypericum elatoides, with neurotrophic activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083129/
https://www.ncbi.nlm.nih.gov/pubmed/35541040
http://dx.doi.org/10.1039/c8ra05322g
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