Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic b...

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Detalles Bibliográficos
Autores principales: Liu, Liang, Deng, Quan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083154/
https://www.ncbi.nlm.nih.gov/pubmed/35259815
http://dx.doi.org/10.4103/1673-5374.335825
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author Liu, Liang
Deng, Quan-Jun
author_facet Liu, Liang
Deng, Quan-Jun
author_sort Liu, Liang
collection PubMed
description Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury. Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury. This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.
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spelling pubmed-90831542022-05-10 Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation Liu, Liang Deng, Quan-Jun Neural Regen Res Review Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury. Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury. This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury. Wolters Kluwer - Medknow 2022-02-28 /pmc/articles/PMC9083154/ /pubmed/35259815 http://dx.doi.org/10.4103/1673-5374.335825 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Liu, Liang
Deng, Quan-Jun
Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title_full Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title_fullStr Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title_full_unstemmed Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title_short Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
title_sort role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083154/
https://www.ncbi.nlm.nih.gov/pubmed/35259815
http://dx.doi.org/10.4103/1673-5374.335825
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AT dengquanjun roleofplateletderivedextracellularvesiclesintraumaticbraininjuryinducedcoagulopathyandinflammation

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