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DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease

The amyloid-β (Aβ) oligomer, rather than the Aβ monomer, is considered to be the primary initiator of Alzheimer’s disease. It was hypothesized that p(Aβ3–10)10-MT, the recombinant Aβ3–10 gene vaccine of the Aβ oligomer has the potential to treat Alzheimer’s disease. In this study, we intramuscularly...

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Detalles Bibliográficos
Autores principales:	Sha, Sha, Xing, Xiao-Na, Wang, Tao, Li, Ying, Zhang, Rong-Wei, Shen, Xue-Li, Cao, Yun-Peng, Qu, Le
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083157/ https://www.ncbi.nlm.nih.gov/pubmed/35259854 http://dx.doi.org/10.4103/1673-5374.337054

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