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Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus, affecting nerves in all parts of the body including corneal nerves and peripheral nervous system, leading to diabetic corneal neuropathy and diabetic peripheral neuropathy, respectively. Diabetic peripheral neuropath...

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Detalles Bibliográficos
Autores principales: So, Wei Zheng, Wong, Natalie Shi Qi, Tan, Hong Chang, Lin, Molly Tzu Yu, Lee, Isabelle Xin Yu, Mehta, Jodhbir S., Liu, Yu-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083173/
https://www.ncbi.nlm.nih.gov/pubmed/35259825
http://dx.doi.org/10.4103/1673-5374.327364
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author So, Wei Zheng
Wong, Natalie Shi Qi
Tan, Hong Chang
Lin, Molly Tzu Yu
Lee, Isabelle Xin Yu
Mehta, Jodhbir S.
Liu, Yu-Chi
author_facet So, Wei Zheng
Wong, Natalie Shi Qi
Tan, Hong Chang
Lin, Molly Tzu Yu
Lee, Isabelle Xin Yu
Mehta, Jodhbir S.
Liu, Yu-Chi
author_sort So, Wei Zheng
collection PubMed
description Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus, affecting nerves in all parts of the body including corneal nerves and peripheral nervous system, leading to diabetic corneal neuropathy and diabetic peripheral neuropathy, respectively. Diabetic peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies, clinical scoring, and skin biopsies. However, these diagnostic methods have limited sensitivity in detecting small-fiber disease, hence they do not accurately reflect the status of diabetic neuropathy. More recently, analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral neuropathy. In this review, we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy, elaborating on the foundational aspects of each: pathogenesis, clinical presentation, evaluation, and management. We will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy, particularly early diabetic peripheral neuropathy; the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy; and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy.
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spelling pubmed-90831732022-05-10 Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy So, Wei Zheng Wong, Natalie Shi Qi Tan, Hong Chang Lin, Molly Tzu Yu Lee, Isabelle Xin Yu Mehta, Jodhbir S. Liu, Yu-Chi Neural Regen Res Review Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus, affecting nerves in all parts of the body including corneal nerves and peripheral nervous system, leading to diabetic corneal neuropathy and diabetic peripheral neuropathy, respectively. Diabetic peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies, clinical scoring, and skin biopsies. However, these diagnostic methods have limited sensitivity in detecting small-fiber disease, hence they do not accurately reflect the status of diabetic neuropathy. More recently, analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral neuropathy. In this review, we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy, elaborating on the foundational aspects of each: pathogenesis, clinical presentation, evaluation, and management. We will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy, particularly early diabetic peripheral neuropathy; the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy; and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy. Wolters Kluwer - Medknow 2022-02-28 /pmc/articles/PMC9083173/ /pubmed/35259825 http://dx.doi.org/10.4103/1673-5374.327364 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
So, Wei Zheng
Wong, Natalie Shi Qi
Tan, Hong Chang
Lin, Molly Tzu Yu
Lee, Isabelle Xin Yu
Mehta, Jodhbir S.
Liu, Yu-Chi
Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title_full Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title_fullStr Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title_full_unstemmed Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title_short Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
title_sort diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083173/
https://www.ncbi.nlm.nih.gov/pubmed/35259825
http://dx.doi.org/10.4103/1673-5374.327364
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