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Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations

The gut microbiome performs many important functions in mammalian hosts, with community composition shaping its functional role. However, the factors that drive individual microbiota variation in wild animals and to what extent these are predictable or idiosyncratic across populations remains poorly...

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Autores principales: Marsh, Kirsty J., Raulo, Aura M., Brouard, Marc, Troitsky, Tanya, English, Holly M., Allen, Bryony, Raval, Rohan, Venkatesan, Saudamini, Pedersen, Amy B., Webster, Joanne P., Knowles, Sarah C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083407/
https://www.ncbi.nlm.nih.gov/pubmed/35547129
http://dx.doi.org/10.3389/fmicb.2022.809735
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author Marsh, Kirsty J.
Raulo, Aura M.
Brouard, Marc
Troitsky, Tanya
English, Holly M.
Allen, Bryony
Raval, Rohan
Venkatesan, Saudamini
Pedersen, Amy B.
Webster, Joanne P.
Knowles, Sarah C. L.
author_facet Marsh, Kirsty J.
Raulo, Aura M.
Brouard, Marc
Troitsky, Tanya
English, Holly M.
Allen, Bryony
Raval, Rohan
Venkatesan, Saudamini
Pedersen, Amy B.
Webster, Joanne P.
Knowles, Sarah C. L.
author_sort Marsh, Kirsty J.
collection PubMed
description The gut microbiome performs many important functions in mammalian hosts, with community composition shaping its functional role. However, the factors that drive individual microbiota variation in wild animals and to what extent these are predictable or idiosyncratic across populations remains poorly understood. Here, we use a multi-population dataset from a common rodent species (the wood mouse, Apodemus sylvaticus), to test whether a consistent “core” gut microbiota is identifiable in this species, and to what extent the predictors of microbiota variation are consistent across populations. Between 2014 and 2018 we used capture-mark-recapture and 16S rRNA profiling to intensively monitor two wild wood mouse populations and their gut microbiota, as well as characterising the microbiota from a laboratory-housed colony of the same species. Although the microbiota was broadly similar at high taxonomic levels, the two wild populations did not share a single bacterial amplicon sequence variant (ASV), despite being only 50km apart. Meanwhile, the laboratory-housed colony shared many ASVs with one of the wild populations from which it is thought to have been founded decades ago. Despite not sharing any ASVs, the two wild populations shared a phylogenetically more similar microbiota than either did with the colony, and the factors predicting compositional variation in each wild population were remarkably similar. We identified a strong and consistent pattern of seasonal microbiota restructuring that occurred at both sites, in all years, and within individual mice. While the microbiota was highly individualised, some seasonal convergence occurred in late winter/early spring. These findings reveal highly repeatable seasonal gut microbiota dynamics in multiple populations of this species, despite different taxa being involved. This provides a platform for future work to understand the drivers and functional implications of such predictable seasonal microbiome restructuring, including whether it might provide the host with adaptive seasonal phenotypic plasticity.
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spelling pubmed-90834072022-05-10 Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations Marsh, Kirsty J. Raulo, Aura M. Brouard, Marc Troitsky, Tanya English, Holly M. Allen, Bryony Raval, Rohan Venkatesan, Saudamini Pedersen, Amy B. Webster, Joanne P. Knowles, Sarah C. L. Front Microbiol Microbiology The gut microbiome performs many important functions in mammalian hosts, with community composition shaping its functional role. However, the factors that drive individual microbiota variation in wild animals and to what extent these are predictable or idiosyncratic across populations remains poorly understood. Here, we use a multi-population dataset from a common rodent species (the wood mouse, Apodemus sylvaticus), to test whether a consistent “core” gut microbiota is identifiable in this species, and to what extent the predictors of microbiota variation are consistent across populations. Between 2014 and 2018 we used capture-mark-recapture and 16S rRNA profiling to intensively monitor two wild wood mouse populations and their gut microbiota, as well as characterising the microbiota from a laboratory-housed colony of the same species. Although the microbiota was broadly similar at high taxonomic levels, the two wild populations did not share a single bacterial amplicon sequence variant (ASV), despite being only 50km apart. Meanwhile, the laboratory-housed colony shared many ASVs with one of the wild populations from which it is thought to have been founded decades ago. Despite not sharing any ASVs, the two wild populations shared a phylogenetically more similar microbiota than either did with the colony, and the factors predicting compositional variation in each wild population were remarkably similar. We identified a strong and consistent pattern of seasonal microbiota restructuring that occurred at both sites, in all years, and within individual mice. While the microbiota was highly individualised, some seasonal convergence occurred in late winter/early spring. These findings reveal highly repeatable seasonal gut microbiota dynamics in multiple populations of this species, despite different taxa being involved. This provides a platform for future work to understand the drivers and functional implications of such predictable seasonal microbiome restructuring, including whether it might provide the host with adaptive seasonal phenotypic plasticity. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9083407/ /pubmed/35547129 http://dx.doi.org/10.3389/fmicb.2022.809735 Text en Copyright © 2022 Marsh, Raulo, Brouard, Troitsky, English, Allen, Raval, Venkatesan, Pedersen, Webster and Knowles. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Marsh, Kirsty J.
Raulo, Aura M.
Brouard, Marc
Troitsky, Tanya
English, Holly M.
Allen, Bryony
Raval, Rohan
Venkatesan, Saudamini
Pedersen, Amy B.
Webster, Joanne P.
Knowles, Sarah C. L.
Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title_full Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title_fullStr Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title_full_unstemmed Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title_short Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations
title_sort synchronous seasonality in the gut microbiota of wild mouse populations
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083407/
https://www.ncbi.nlm.nih.gov/pubmed/35547129
http://dx.doi.org/10.3389/fmicb.2022.809735
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