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Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to id...

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Detalles Bibliográficos
Autores principales: Bakonyi, Mónika, Gácsi, Attila, Berkó, Szilvia, Kovács, Anita, Csányi, Erzsébet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083441/
https://www.ncbi.nlm.nih.gov/pubmed/35539999
http://dx.doi.org/10.1039/c8ra04129f
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author Bakonyi, Mónika
Gácsi, Attila
Berkó, Szilvia
Kovács, Anita
Csányi, Erzsébet
author_facet Bakonyi, Mónika
Gácsi, Attila
Berkó, Szilvia
Kovács, Anita
Csányi, Erzsébet
author_sort Bakonyi, Mónika
collection PubMed
description Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to identify possible correlations of the biological effectiveness of penetration enhancers with their interaction with a well-defined model system consisting of skin mimic lipid bilayers, as determined by calcein release experiments using stratum corneum lipid liposomes (SCLLs). We aimed to investigate the enhancing effects of different concentrations of two chemical penetration enhancers, Kolliphor RH40 and Transcutol on SCLLs. The results obtained by SCLL-based techniques were compared with conventional ex vivo penetration studies in case of Kolliphor RH40 to evaluate the potential of SCLLs as an alternative tool for screening various types and concentrations of penetration enhancers. As a result, calcein leakage assay performed with SCLL was considered to be a good model for the skin penetration enhancing effect. This method could be used as a time-saving and sensitive alternative in vitro screening technique in the early stage of the development of dermal formulations.
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spelling pubmed-90834412022-05-09 Stratum corneum lipid liposomes for investigating skin penetration enhancer effects Bakonyi, Mónika Gácsi, Attila Berkó, Szilvia Kovács, Anita Csányi, Erzsébet RSC Adv Chemistry Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to identify possible correlations of the biological effectiveness of penetration enhancers with their interaction with a well-defined model system consisting of skin mimic lipid bilayers, as determined by calcein release experiments using stratum corneum lipid liposomes (SCLLs). We aimed to investigate the enhancing effects of different concentrations of two chemical penetration enhancers, Kolliphor RH40 and Transcutol on SCLLs. The results obtained by SCLL-based techniques were compared with conventional ex vivo penetration studies in case of Kolliphor RH40 to evaluate the potential of SCLLs as an alternative tool for screening various types and concentrations of penetration enhancers. As a result, calcein leakage assay performed with SCLL was considered to be a good model for the skin penetration enhancing effect. This method could be used as a time-saving and sensitive alternative in vitro screening technique in the early stage of the development of dermal formulations. The Royal Society of Chemistry 2018-08-02 /pmc/articles/PMC9083441/ /pubmed/35539999 http://dx.doi.org/10.1039/c8ra04129f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Bakonyi, Mónika
Gácsi, Attila
Berkó, Szilvia
Kovács, Anita
Csányi, Erzsébet
Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title_full Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title_fullStr Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title_full_unstemmed Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title_short Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
title_sort stratum corneum lipid liposomes for investigating skin penetration enhancer effects
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083441/
https://www.ncbi.nlm.nih.gov/pubmed/35539999
http://dx.doi.org/10.1039/c8ra04129f
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