Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening

A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylpheneth...

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Autores principales: Saavedra-Olavarría, Jorge, Madrid-Rojas, Matías, Almodovar, Iriux, Hermosilla-Ibáñez, Patricio, Pérez, Edwin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083506/
https://www.ncbi.nlm.nih.gov/pubmed/35542724
http://dx.doi.org/10.1039/c8ra03815e
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author Saavedra-Olavarría, Jorge
Madrid-Rojas, Matías
Almodovar, Iriux
Hermosilla-Ibáñez, Patricio
Pérez, Edwin G.
author_facet Saavedra-Olavarría, Jorge
Madrid-Rojas, Matías
Almodovar, Iriux
Hermosilla-Ibáñez, Patricio
Pérez, Edwin G.
author_sort Saavedra-Olavarría, Jorge
collection PubMed
description A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.
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spelling pubmed-90835062022-05-09 Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening Saavedra-Olavarría, Jorge Madrid-Rojas, Matías Almodovar, Iriux Hermosilla-Ibáñez, Patricio Pérez, Edwin G. RSC Adv Chemistry A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands. The Royal Society of Chemistry 2018-08-06 /pmc/articles/PMC9083506/ /pubmed/35542724 http://dx.doi.org/10.1039/c8ra03815e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Saavedra-Olavarría, Jorge
Madrid-Rojas, Matías
Almodovar, Iriux
Hermosilla-Ibáñez, Patricio
Pérez, Edwin G.
Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title_full Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title_fullStr Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title_full_unstemmed Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title_short Synthesis of β-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
title_sort synthesis of β-alkoxy-n-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083506/
https://www.ncbi.nlm.nih.gov/pubmed/35542724
http://dx.doi.org/10.1039/c8ra03815e
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