Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication and genomic instability. CDT1 is a critical fac...

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Detalles Bibliográficos
Autores principales: Karantzelis, Nikolaos, Petropoulos, Michalis, De Marco, Valeria, Egan, David A., Fish, Alexander, Christodoulou, Evangelos, Will, David W., Lewis, Joe D., Perrakis, Anastassis, Lygerou, Zoi, Taraviras, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083542/
https://www.ncbi.nlm.nih.gov/pubmed/35548337
http://dx.doi.org/10.3389/fphar.2022.860682

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