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Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083545/ https://www.ncbi.nlm.nih.gov/pubmed/35548351 http://dx.doi.org/10.3389/fphar.2022.864081 |
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author | Chen, Qiying Wang, Qiaohong Zhang, Yin |
author_facet | Chen, Qiying Wang, Qiaohong Zhang, Yin |
author_sort | Chen, Qiying |
collection | PubMed |
description | This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences in the overall rate of rational PPI use, proportion of unindicated PPI use, utilization rate, average defined daily dose (DDD), drug costs, PPI costs, and cost-effectiveness of clinical pharmacist intervention between the intervention (538 cases) and control (536 cases) groups. In the intervention group, Pareto and fishbone diagram analyses were combined with the Plan-Do-Check-Act cycle; Statistical Package for the Social Sciences was used for analyzing all data. The overall rate of rational PPI use was significantly higher in the intervention group than in the control group (p < 0.01). The proportion of unindicated PPI use, utilization rate, average DDD, drug costs, and PPI costs were significantly lower in the intervention group than in the control group (p < 0.05). Cost-effectiveness analysis for the overall rate of rational PPI use indicated a positive impact of intervention, with economic benefits in the intervention group. Clinical pharmacist intervention for rational use of PPIs in general surgery departments could significantly increase the overall rate of rational PPI use; it could also reduce the proportion of unindicated PPI use, utilization rates, average DDDs, drug costs, and PPIs costs. Pharmacist intervention also offers economic benefits by improving the overall rate of rational PPI use. |
format | Online Article Text |
id | pubmed-9083545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90835452022-05-10 Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department Chen, Qiying Wang, Qiaohong Zhang, Yin Front Pharmacol Pharmacology This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences in the overall rate of rational PPI use, proportion of unindicated PPI use, utilization rate, average defined daily dose (DDD), drug costs, PPI costs, and cost-effectiveness of clinical pharmacist intervention between the intervention (538 cases) and control (536 cases) groups. In the intervention group, Pareto and fishbone diagram analyses were combined with the Plan-Do-Check-Act cycle; Statistical Package for the Social Sciences was used for analyzing all data. The overall rate of rational PPI use was significantly higher in the intervention group than in the control group (p < 0.01). The proportion of unindicated PPI use, utilization rate, average DDD, drug costs, and PPI costs were significantly lower in the intervention group than in the control group (p < 0.05). Cost-effectiveness analysis for the overall rate of rational PPI use indicated a positive impact of intervention, with economic benefits in the intervention group. Clinical pharmacist intervention for rational use of PPIs in general surgery departments could significantly increase the overall rate of rational PPI use; it could also reduce the proportion of unindicated PPI use, utilization rates, average DDDs, drug costs, and PPIs costs. Pharmacist intervention also offers economic benefits by improving the overall rate of rational PPI use. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9083545/ /pubmed/35548351 http://dx.doi.org/10.3389/fphar.2022.864081 Text en Copyright © 2022 Chen, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chen, Qiying Wang, Qiaohong Zhang, Yin Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title | Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title_full | Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title_fullStr | Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title_full_unstemmed | Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title_short | Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department |
title_sort | clinical intervention increases rational use of proton pump inhibitors in the general surgery department |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083545/ https://www.ncbi.nlm.nih.gov/pubmed/35548351 http://dx.doi.org/10.3389/fphar.2022.864081 |
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