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Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department

This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences i...

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Autores principales: Chen, Qiying, Wang, Qiaohong, Zhang, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083545/
https://www.ncbi.nlm.nih.gov/pubmed/35548351
http://dx.doi.org/10.3389/fphar.2022.864081
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author Chen, Qiying
Wang, Qiaohong
Zhang, Yin
author_facet Chen, Qiying
Wang, Qiaohong
Zhang, Yin
author_sort Chen, Qiying
collection PubMed
description This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences in the overall rate of rational PPI use, proportion of unindicated PPI use, utilization rate, average defined daily dose (DDD), drug costs, PPI costs, and cost-effectiveness of clinical pharmacist intervention between the intervention (538 cases) and control (536 cases) groups. In the intervention group, Pareto and fishbone diagram analyses were combined with the Plan-Do-Check-Act cycle; Statistical Package for the Social Sciences was used for analyzing all data. The overall rate of rational PPI use was significantly higher in the intervention group than in the control group (p < 0.01). The proportion of unindicated PPI use, utilization rate, average DDD, drug costs, and PPI costs were significantly lower in the intervention group than in the control group (p < 0.05). Cost-effectiveness analysis for the overall rate of rational PPI use indicated a positive impact of intervention, with economic benefits in the intervention group. Clinical pharmacist intervention for rational use of PPIs in general surgery departments could significantly increase the overall rate of rational PPI use; it could also reduce the proportion of unindicated PPI use, utilization rates, average DDDs, drug costs, and PPIs costs. Pharmacist intervention also offers economic benefits by improving the overall rate of rational PPI use.
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spelling pubmed-90835452022-05-10 Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department Chen, Qiying Wang, Qiaohong Zhang, Yin Front Pharmacol Pharmacology This study aimed to evaluate the role of the clinical pharmacist in the rational use of proton pump inhibitors (PPIs) in a general surgery department. All enrolled patients had attended the general surgery department of a tertiary hospital. This single-center prospective study compared differences in the overall rate of rational PPI use, proportion of unindicated PPI use, utilization rate, average defined daily dose (DDD), drug costs, PPI costs, and cost-effectiveness of clinical pharmacist intervention between the intervention (538 cases) and control (536 cases) groups. In the intervention group, Pareto and fishbone diagram analyses were combined with the Plan-Do-Check-Act cycle; Statistical Package for the Social Sciences was used for analyzing all data. The overall rate of rational PPI use was significantly higher in the intervention group than in the control group (p < 0.01). The proportion of unindicated PPI use, utilization rate, average DDD, drug costs, and PPI costs were significantly lower in the intervention group than in the control group (p < 0.05). Cost-effectiveness analysis for the overall rate of rational PPI use indicated a positive impact of intervention, with economic benefits in the intervention group. Clinical pharmacist intervention for rational use of PPIs in general surgery departments could significantly increase the overall rate of rational PPI use; it could also reduce the proportion of unindicated PPI use, utilization rates, average DDDs, drug costs, and PPIs costs. Pharmacist intervention also offers economic benefits by improving the overall rate of rational PPI use. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9083545/ /pubmed/35548351 http://dx.doi.org/10.3389/fphar.2022.864081 Text en Copyright © 2022 Chen, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Qiying
Wang, Qiaohong
Zhang, Yin
Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title_full Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title_fullStr Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title_full_unstemmed Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title_short Clinical Intervention Increases Rational Use of Proton Pump Inhibitors in the General Surgery Department
title_sort clinical intervention increases rational use of proton pump inhibitors in the general surgery department
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083545/
https://www.ncbi.nlm.nih.gov/pubmed/35548351
http://dx.doi.org/10.3389/fphar.2022.864081
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