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Computational Analysis on the Allostery of Tryptophan Synthase: Relationship between α/β-Ligand Binding and Distal Domain Closure
[Image: see text] Tryptophan synthase (TRPS) is a bifunctional enzyme consisting of α and β-subunits and catalyzes the last two steps of l-tryptophan (L-Trp) biosynthesis, namely, cleavage of 3-indole-d-glycerol-3′-phosphate (IGP) into indole and glyceraldehyde-3-phosphate (G3P) in the α-subunit, an...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083551/ https://www.ncbi.nlm.nih.gov/pubmed/35446577 http://dx.doi.org/10.1021/acs.jpcb.2c01556 |