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Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology
BACKGROUND: Fibrous hamartoma of infancy (FHI) is a rare soft tissue lesion arising as a subcutaneous mass involving the axilla, trunk, and upper arm in infants and children <2yrs. Sarcomatous transformation in FHI is described in anecdotal cases in the literature. CASE REPORT: We describe one su...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital Universitário da Universidade de São Paulo
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083879/ https://www.ncbi.nlm.nih.gov/pubmed/35574046 http://dx.doi.org/10.4322/acr.2021.380 |
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author | Kapatia, Gargi Chatterjee, Debajyoti Gupta, Kirti Trehan, Amita |
author_facet | Kapatia, Gargi Chatterjee, Debajyoti Gupta, Kirti Trehan, Amita |
author_sort | Kapatia, Gargi |
collection | PubMed |
description | BACKGROUND: Fibrous hamartoma of infancy (FHI) is a rare soft tissue lesion arising as a subcutaneous mass involving the axilla, trunk, and upper arm in infants and children <2yrs. Sarcomatous transformation in FHI is described in anecdotal cases in the literature. CASE REPORT: We describe one such example arising as a mass in the lower back in a 3-month-old infant. On histology, the tumor contained classic triphasic morphology; however, brisk mitotic activity noted at multiple foci was diagnostically challenging to categorize. The tumor was evaluated for ETV6-NTRK3 fusion to exclude other common differentials. CONCLUSION: While FHI may be frequently encountered in infants, rare sarcomatous transformation are known to occur and merits special attention as it can be misdiagnosed. Also, a close follow-up is warranted as the lesion is known to recur locally. |
format | Online Article Text |
id | pubmed-9083879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hospital Universitário da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-90838792022-05-14 Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology Kapatia, Gargi Chatterjee, Debajyoti Gupta, Kirti Trehan, Amita Autops Case Rep Clinical Case Report BACKGROUND: Fibrous hamartoma of infancy (FHI) is a rare soft tissue lesion arising as a subcutaneous mass involving the axilla, trunk, and upper arm in infants and children <2yrs. Sarcomatous transformation in FHI is described in anecdotal cases in the literature. CASE REPORT: We describe one such example arising as a mass in the lower back in a 3-month-old infant. On histology, the tumor contained classic triphasic morphology; however, brisk mitotic activity noted at multiple foci was diagnostically challenging to categorize. The tumor was evaluated for ETV6-NTRK3 fusion to exclude other common differentials. CONCLUSION: While FHI may be frequently encountered in infants, rare sarcomatous transformation are known to occur and merits special attention as it can be misdiagnosed. Also, a close follow-up is warranted as the lesion is known to recur locally. Hospital Universitário da Universidade de São Paulo 2022-04-28 /pmc/articles/PMC9083879/ /pubmed/35574046 http://dx.doi.org/10.4322/acr.2021.380 Text en Copyright © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Case Report Kapatia, Gargi Chatterjee, Debajyoti Gupta, Kirti Trehan, Amita Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title | Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title_full | Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title_fullStr | Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title_full_unstemmed | Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title_short | Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
title_sort | fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology |
topic | Clinical Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083879/ https://www.ncbi.nlm.nih.gov/pubmed/35574046 http://dx.doi.org/10.4322/acr.2021.380 |
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