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Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study
BACKGROUND: Serum total bilirubin has been reported to have antioxidant properties against chronic respiratory diseases. The objective of our study is to evaluate the association of total bilirubin (TB) with annual lung function decline in COPD patients with different GOLD stages. METHODS: This stud...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084194/ https://www.ncbi.nlm.nih.gov/pubmed/35547779 http://dx.doi.org/10.2147/COPD.S360485 |
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author | Dai, Cuiqiong Wang, Zihui Deng, Zhishan Wu, Fan Yang, Huajing Xiao, Shan Wen, Xiang Zheng, Youlan Xu, Jianwu Lu, Lifei Zhao, Ningning Huang, Peiyu Zhou, Yumin Ran, Pixin |
author_facet | Dai, Cuiqiong Wang, Zihui Deng, Zhishan Wu, Fan Yang, Huajing Xiao, Shan Wen, Xiang Zheng, Youlan Xu, Jianwu Lu, Lifei Zhao, Ningning Huang, Peiyu Zhou, Yumin Ran, Pixin |
author_sort | Dai, Cuiqiong |
collection | PubMed |
description | BACKGROUND: Serum total bilirubin has been reported to have antioxidant properties against chronic respiratory diseases. The objective of our study is to evaluate the association of total bilirubin (TB) with annual lung function decline in COPD patients with different GOLD stages. METHODS: This study used pooled data from two observational and prospective cohorts of 612 COPD patients whose TB levels were measured at baseline. The associations between TB and postbronchodilator FEV(1), FEV(1)pred, FVC, FVCpred, FEV(1)/FVC, and the rate of their decline were all determined using linear regression models in the total population and strata of GOLD stages. RESULTS: Serum TB was positively related to FEV(1) and FVC in the total group (β 0.02, 95% CI 0.001~0.02, P = 0.025 and β 0.02, 95% CI 0.002~0.03, P = 0.022, respectively). Additionally, TB was inversely associated with the annual decline in FEV(1) and FEV(1)pred (β 4.91, 95% CI 1.68~8.14, P = 0.025 and β 0.21, 95% CI 0.06~0.36, P = 0.022, respectively) when adjusted for multivariables. After stratification, the significant associations merely persisted in COPD patients with GOLD 2 and GOLD 3–4. CONCLUSION: Increased TB level was related to less annual decline in FEV(1) as well as FEV(1)pred in moderate-to-severe COPD but not mild COPD, which indicated the different status of TB in different COPD severity and the possible role as potential biomarker merely in moderate-to-severe COPD. Future researches to determine whether TB could be served as biomarker for COPD and the mechanisms should be focused on some target patients with a certain disease severity. |
format | Online Article Text |
id | pubmed-9084194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-90841942022-05-10 Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study Dai, Cuiqiong Wang, Zihui Deng, Zhishan Wu, Fan Yang, Huajing Xiao, Shan Wen, Xiang Zheng, Youlan Xu, Jianwu Lu, Lifei Zhao, Ningning Huang, Peiyu Zhou, Yumin Ran, Pixin Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Serum total bilirubin has been reported to have antioxidant properties against chronic respiratory diseases. The objective of our study is to evaluate the association of total bilirubin (TB) with annual lung function decline in COPD patients with different GOLD stages. METHODS: This study used pooled data from two observational and prospective cohorts of 612 COPD patients whose TB levels were measured at baseline. The associations between TB and postbronchodilator FEV(1), FEV(1)pred, FVC, FVCpred, FEV(1)/FVC, and the rate of their decline were all determined using linear regression models in the total population and strata of GOLD stages. RESULTS: Serum TB was positively related to FEV(1) and FVC in the total group (β 0.02, 95% CI 0.001~0.02, P = 0.025 and β 0.02, 95% CI 0.002~0.03, P = 0.022, respectively). Additionally, TB was inversely associated with the annual decline in FEV(1) and FEV(1)pred (β 4.91, 95% CI 1.68~8.14, P = 0.025 and β 0.21, 95% CI 0.06~0.36, P = 0.022, respectively) when adjusted for multivariables. After stratification, the significant associations merely persisted in COPD patients with GOLD 2 and GOLD 3–4. CONCLUSION: Increased TB level was related to less annual decline in FEV(1) as well as FEV(1)pred in moderate-to-severe COPD but not mild COPD, which indicated the different status of TB in different COPD severity and the possible role as potential biomarker merely in moderate-to-severe COPD. Future researches to determine whether TB could be served as biomarker for COPD and the mechanisms should be focused on some target patients with a certain disease severity. Dove 2022-05-05 /pmc/articles/PMC9084194/ /pubmed/35547779 http://dx.doi.org/10.2147/COPD.S360485 Text en © 2022 Dai et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Dai, Cuiqiong Wang, Zihui Deng, Zhishan Wu, Fan Yang, Huajing Xiao, Shan Wen, Xiang Zheng, Youlan Xu, Jianwu Lu, Lifei Zhao, Ningning Huang, Peiyu Zhou, Yumin Ran, Pixin Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title | Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title_full | Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title_fullStr | Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title_full_unstemmed | Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title_short | Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study |
title_sort | association between serum total bilirubin level and lung function decline in patients with copd: results from a pooled study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084194/ https://www.ncbi.nlm.nih.gov/pubmed/35547779 http://dx.doi.org/10.2147/COPD.S360485 |
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