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Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease
BACKGROUND: The effect of serum uric acid (SUA) levels on lung function in chronic obstructive pulmonary disease (COPD) people remained unclear. We aimed to investigate the association between SUA and lung function. METHODS: A cross-sectional study was performed to measure the SUA levels and lung fu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084221/ https://www.ncbi.nlm.nih.gov/pubmed/35547782 http://dx.doi.org/10.2147/COPD.S356797 |
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author | Yang, Huajing Wang, Zihui Xiao, Shan Dai, Cuiqiong Wen, Xiang Wu, Fan Peng, Jieqi Tian, Heshan Zhou, Yumin Ran, Pixin |
author_facet | Yang, Huajing Wang, Zihui Xiao, Shan Dai, Cuiqiong Wen, Xiang Wu, Fan Peng, Jieqi Tian, Heshan Zhou, Yumin Ran, Pixin |
author_sort | Yang, Huajing |
collection | PubMed |
description | BACKGROUND: The effect of serum uric acid (SUA) levels on lung function in chronic obstructive pulmonary disease (COPD) people remained unclear. We aimed to investigate the association between SUA and lung function. METHODS: A cross-sectional study was performed to measure the SUA levels and lung function in 2797 consecutive eligible individuals. Of these, individuals in our study were divided into two groups, the COPD group (n=1387) and the non-COPD group (n=1410). The diagnosis of COPD is defined as post-bronchodilator first second of forced expiratory volume (FEV(1))/forced vital capacity (FVC) ratio of less than 0.70. Multivariable adjustment linear models were applied to estimate the effect of SUA levels on FEV(1)% predicted, FVC% predicted, and FEV(1)/FVC stratified by COPD status. RESULTS: After multivariable adjustment, each 1 mg/dL increase of SUA was significantly associated with a decrease in FEV(1)% predicted (−1.63%, 95% confidence interval [CI] −2.37 to −0.90), FVC % predicted (−0.89%, 95% CI −1.55 to −0.24), and FEV(1)/FVC (−0.70%, 95% CI −1.10 to −0.30). In the COPD group, each 1 mg/dL increase of SUA was significantly associated with decreases in FEV(1)% predicted (−1.87%, 95% CI −2.91 to −0.84), FVC% predicted (−1.35%, 95% CI −2.35 to −0.34), and FEV(1)/FVC (−0.63%, 95% CI −1.18 to −0.08). However, no significant association between lung function and SUA was found among people without COPD. CONCLUSION: High SUA levels were associated with lower lung function, especially in COPD patients. However, no statistically significant effect of SUA on lung function was found in people without COPD. |
format | Online Article Text |
id | pubmed-9084221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-90842212022-05-10 Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease Yang, Huajing Wang, Zihui Xiao, Shan Dai, Cuiqiong Wen, Xiang Wu, Fan Peng, Jieqi Tian, Heshan Zhou, Yumin Ran, Pixin Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: The effect of serum uric acid (SUA) levels on lung function in chronic obstructive pulmonary disease (COPD) people remained unclear. We aimed to investigate the association between SUA and lung function. METHODS: A cross-sectional study was performed to measure the SUA levels and lung function in 2797 consecutive eligible individuals. Of these, individuals in our study were divided into two groups, the COPD group (n=1387) and the non-COPD group (n=1410). The diagnosis of COPD is defined as post-bronchodilator first second of forced expiratory volume (FEV(1))/forced vital capacity (FVC) ratio of less than 0.70. Multivariable adjustment linear models were applied to estimate the effect of SUA levels on FEV(1)% predicted, FVC% predicted, and FEV(1)/FVC stratified by COPD status. RESULTS: After multivariable adjustment, each 1 mg/dL increase of SUA was significantly associated with a decrease in FEV(1)% predicted (−1.63%, 95% confidence interval [CI] −2.37 to −0.90), FVC % predicted (−0.89%, 95% CI −1.55 to −0.24), and FEV(1)/FVC (−0.70%, 95% CI −1.10 to −0.30). In the COPD group, each 1 mg/dL increase of SUA was significantly associated with decreases in FEV(1)% predicted (−1.87%, 95% CI −2.91 to −0.84), FVC% predicted (−1.35%, 95% CI −2.35 to −0.34), and FEV(1)/FVC (−0.63%, 95% CI −1.18 to −0.08). However, no significant association between lung function and SUA was found among people without COPD. CONCLUSION: High SUA levels were associated with lower lung function, especially in COPD patients. However, no statistically significant effect of SUA on lung function was found in people without COPD. Dove 2022-05-05 /pmc/articles/PMC9084221/ /pubmed/35547782 http://dx.doi.org/10.2147/COPD.S356797 Text en © 2022 Yang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Yang, Huajing Wang, Zihui Xiao, Shan Dai, Cuiqiong Wen, Xiang Wu, Fan Peng, Jieqi Tian, Heshan Zhou, Yumin Ran, Pixin Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title | Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title_full | Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title_fullStr | Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title_short | Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease |
title_sort | association between serum uric acid and lung function in people with and without chronic obstructive pulmonary disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084221/ https://www.ncbi.nlm.nih.gov/pubmed/35547782 http://dx.doi.org/10.2147/COPD.S356797 |
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