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Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery

Lipid nanoparticles (LNPs) can be used as delivery vehicles for nucleic acid biotherapeutics. In fact, LNPs are currently being used in the Pfizer/BioNTech and Moderna COVID-19 vaccines. Cationic LNPs composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)/cholesterol (chol) LNPs have been clas...

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Detalles Bibliográficos
Autores principales:	Sun, Mengwei, Dang, Utkarsh J., Yuan, Yuhao, Psaras, Alexandra Maria, Osipitan, Ositomiwa, Brooks, Tracy A., Lu, Fake, Di Pasqua, Anthony J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084260/ https://www.ncbi.nlm.nih.gov/pubmed/35534697 http://dx.doi.org/10.1208/s12249-022-02294-w

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