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Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius

Trans-generational immune priming involves the transfer of immunological experience, acquired by the parents after exposure to pathogens, to protect their progeny against infections by these pathogens. Such natural mechanisms could be exploited to prevent disease expression in economically important...

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Autores principales: Ory, Florine, Duchemin, Vincent, Kilchenmann, Verena, Charrière, Jean-Daniel, Dainat, Benjamin, Dietemann, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084521/
https://www.ncbi.nlm.nih.gov/pubmed/35533189
http://dx.doi.org/10.1371/journal.pone.0268142
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author Ory, Florine
Duchemin, Vincent
Kilchenmann, Verena
Charrière, Jean-Daniel
Dainat, Benjamin
Dietemann, Vincent
author_facet Ory, Florine
Duchemin, Vincent
Kilchenmann, Verena
Charrière, Jean-Daniel
Dainat, Benjamin
Dietemann, Vincent
author_sort Ory, Florine
collection PubMed
description Trans-generational immune priming involves the transfer of immunological experience, acquired by the parents after exposure to pathogens, to protect their progeny against infections by these pathogens. Such natural mechanisms could be exploited to prevent disease expression in economically important insects, such as the honey bee. This mechanism occurs when honey bee queens are exposed to the pathogenic bacterium Paenibacillus larvae. Here, we tested whether natural or experimental exposure to Melissococcus plutonius—another bacterium triggering a disease in honey bee larvae—reduced the susceptibility of the queen’s progeny to infection by this pathogen. Because the immunological response upon pathogen exposure can lead to fitness costs, we also determined whether experimental exposure of the queens affected them or their colony negatively. Neither natural nor experimental exposure induced protection in the honey bee larvae against the deleterious effects of M. plutonius. Our results provided no evidence for the occurrence of trans-generational immune priming upon exposure of the queen to M. plutonius. Whether this lack was due to confounding genetic resistance, to unsuitable exposure procedure or to the absence of trans-generational immune priming against this pathogen in honey bees remains to be determined.
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spelling pubmed-90845212022-05-10 Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius Ory, Florine Duchemin, Vincent Kilchenmann, Verena Charrière, Jean-Daniel Dainat, Benjamin Dietemann, Vincent PLoS One Research Article Trans-generational immune priming involves the transfer of immunological experience, acquired by the parents after exposure to pathogens, to protect their progeny against infections by these pathogens. Such natural mechanisms could be exploited to prevent disease expression in economically important insects, such as the honey bee. This mechanism occurs when honey bee queens are exposed to the pathogenic bacterium Paenibacillus larvae. Here, we tested whether natural or experimental exposure to Melissococcus plutonius—another bacterium triggering a disease in honey bee larvae—reduced the susceptibility of the queen’s progeny to infection by this pathogen. Because the immunological response upon pathogen exposure can lead to fitness costs, we also determined whether experimental exposure of the queens affected them or their colony negatively. Neither natural nor experimental exposure induced protection in the honey bee larvae against the deleterious effects of M. plutonius. Our results provided no evidence for the occurrence of trans-generational immune priming upon exposure of the queen to M. plutonius. Whether this lack was due to confounding genetic resistance, to unsuitable exposure procedure or to the absence of trans-generational immune priming against this pathogen in honey bees remains to be determined. Public Library of Science 2022-05-09 /pmc/articles/PMC9084521/ /pubmed/35533189 http://dx.doi.org/10.1371/journal.pone.0268142 Text en © 2022 Ory et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ory, Florine
Duchemin, Vincent
Kilchenmann, Verena
Charrière, Jean-Daniel
Dainat, Benjamin
Dietemann, Vincent
Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title_full Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title_fullStr Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title_full_unstemmed Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title_short Lack of evidence for trans-generational immune priming against the honey bee pathogen Melissococcus plutonius
title_sort lack of evidence for trans-generational immune priming against the honey bee pathogen melissococcus plutonius
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084521/
https://www.ncbi.nlm.nih.gov/pubmed/35533189
http://dx.doi.org/10.1371/journal.pone.0268142
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