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Epigenetic modification regulates tumor progression and metastasis through EMT (Review)

Epigenetics is the study of heritable molecular determinants that are independent of phenotypic features. The epigenetic features include DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In multicellular organisms, the epigenetic state of a cell is critical in deter...

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Autores principales: Tan, Tingshan, Shi, Pengfei, Abbas, Muhammad Nadeem, Wang, Yi, Xu, Jie, Chen, Yu, Cui, Hongjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084613/
https://www.ncbi.nlm.nih.gov/pubmed/35445731
http://dx.doi.org/10.3892/ijo.2022.5360
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author Tan, Tingshan
Shi, Pengfei
Abbas, Muhammad Nadeem
Wang, Yi
Xu, Jie
Chen, Yu
Cui, Hongjuan
author_facet Tan, Tingshan
Shi, Pengfei
Abbas, Muhammad Nadeem
Wang, Yi
Xu, Jie
Chen, Yu
Cui, Hongjuan
author_sort Tan, Tingshan
collection PubMed
description Epigenetics is the study of heritable molecular determinants that are independent of phenotypic features. The epigenetic features include DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In multicellular organisms, the epigenetic state of a cell is critical in determining its differentiation status and its ability to perform its proper function. These processes are now well recognized as being a substantial factor in tumor progression and metastasis. The process through which epithelial cells acquire mesenchymal features is known as epithelial-mesenchymal transition (EMT). EMT is associated with tumorigenesis, invasion, metastasis, and resistance to therapy in cancer. In the present review, we examine the recent studies that demonstrate the biological role of epigenetics, in particular, DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling in tumor progression and metastasis by regulating EMT status, and we provide an overview of the current state of knowledge regarding the epigenetics involvement in tumor progression and metastasis. Because epigenetic changes can be reversed, learning more about their biological roles in EMT will not only help us better understand how cancer progresses and spreads, but it will also help us identify new ways to diagnose and treat human malignancy which is currently lacking in the clinical setting.
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spelling pubmed-90846132022-05-10 Epigenetic modification regulates tumor progression and metastasis through EMT (Review) Tan, Tingshan Shi, Pengfei Abbas, Muhammad Nadeem Wang, Yi Xu, Jie Chen, Yu Cui, Hongjuan Int J Oncol Articles Epigenetics is the study of heritable molecular determinants that are independent of phenotypic features. The epigenetic features include DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling. In multicellular organisms, the epigenetic state of a cell is critical in determining its differentiation status and its ability to perform its proper function. These processes are now well recognized as being a substantial factor in tumor progression and metastasis. The process through which epithelial cells acquire mesenchymal features is known as epithelial-mesenchymal transition (EMT). EMT is associated with tumorigenesis, invasion, metastasis, and resistance to therapy in cancer. In the present review, we examine the recent studies that demonstrate the biological role of epigenetics, in particular, DNA methylation, histone modifications, non-coding RNAs, and chromatin remodeling in tumor progression and metastasis by regulating EMT status, and we provide an overview of the current state of knowledge regarding the epigenetics involvement in tumor progression and metastasis. Because epigenetic changes can be reversed, learning more about their biological roles in EMT will not only help us better understand how cancer progresses and spreads, but it will also help us identify new ways to diagnose and treat human malignancy which is currently lacking in the clinical setting. D.A. Spandidos 2022-04-21 /pmc/articles/PMC9084613/ /pubmed/35445731 http://dx.doi.org/10.3892/ijo.2022.5360 Text en Copyright: © Tan et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Tan, Tingshan
Shi, Pengfei
Abbas, Muhammad Nadeem
Wang, Yi
Xu, Jie
Chen, Yu
Cui, Hongjuan
Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title_full Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title_fullStr Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title_full_unstemmed Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title_short Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
title_sort epigenetic modification regulates tumor progression and metastasis through emt (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084613/
https://www.ncbi.nlm.nih.gov/pubmed/35445731
http://dx.doi.org/10.3892/ijo.2022.5360
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