Ligand binding remodels protein side-chain conformational heterogeneity

While protein conformational heterogeneity plays an important role in many aspects of biological function, including ligand binding, its impact has been difficult to quantify. Macromolecular X-ray diffraction is commonly interpreted with a static structure, but it can provide information on both the...

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Detalles Bibliográficos
Autores principales: Wankowicz, Stephanie A, de Oliveira, Saulo H, Hogan, Daniel W, van den Bedem, Henry, Fraser, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084896/
https://www.ncbi.nlm.nih.gov/pubmed/35312477
http://dx.doi.org/10.7554/eLife.74114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084896/
https://www.ncbi.nlm.nih.gov/pubmed/35312477
http://dx.doi.org/10.7554/eLife.74114

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