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Reimagining How We Treat Acute Pain: A Narrative Review

Acute pain may be influenced by biopsychosocial factors. Conditioned pain modulation, distraction, peripheral nerve stimulation, and cryoneurolysis may be helpful in its treatment. New developments in opioids, such as opioids with bifunctional targets and oliceridine, may be particularly suited for...

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Autores principales: Castroman, Pablo, Quiroga, Ovelio, Mayoral Rojals, Victor, Gómez, Maria, Moka, Eleni, Pergolizzi Jr, Joseph, Varrassi, Giustino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084930/
https://www.ncbi.nlm.nih.gov/pubmed/35547466
http://dx.doi.org/10.7759/cureus.23992
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author Castroman, Pablo
Quiroga, Ovelio
Mayoral Rojals, Victor
Gómez, Maria
Moka, Eleni
Pergolizzi Jr, Joseph
Varrassi, Giustino
author_facet Castroman, Pablo
Quiroga, Ovelio
Mayoral Rojals, Victor
Gómez, Maria
Moka, Eleni
Pergolizzi Jr, Joseph
Varrassi, Giustino
author_sort Castroman, Pablo
collection PubMed
description Acute pain may be influenced by biopsychosocial factors. Conditioned pain modulation, distraction, peripheral nerve stimulation, and cryoneurolysis may be helpful in its treatment. New developments in opioids, such as opioids with bifunctional targets and oliceridine, may be particularly suited for acute pain care. Allosteric modulators can enhance receptor subtype selectivity, offering analgesia with fewer and/or less severe side effects. Neuroinflammation in acute pain is caused by direct insult to the central nervous system and is distinct from neuroinflammation in degenerative disorders. Pharmacologic agents targeting the neuroinflammatory process are limited at this time. Postoperative pain is a prevalent form of acute pain and must be recognized as a global public health challenge. This type of pain may be severe, impede rehabilitation, and is often under-treated. A subset of surgical patients develops chronic postsurgical pain. Acute pain is not just temporally limited pain that often resolves on its own. It is an important subject for further research as acute pain may transition into more damaging and debilitating chronic pain. Reimagining how we treat acute pain will help us better address this urgent unmet medical need. 
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spelling pubmed-90849302022-05-10 Reimagining How We Treat Acute Pain: A Narrative Review Castroman, Pablo Quiroga, Ovelio Mayoral Rojals, Victor Gómez, Maria Moka, Eleni Pergolizzi Jr, Joseph Varrassi, Giustino Cureus Pain Management Acute pain may be influenced by biopsychosocial factors. Conditioned pain modulation, distraction, peripheral nerve stimulation, and cryoneurolysis may be helpful in its treatment. New developments in opioids, such as opioids with bifunctional targets and oliceridine, may be particularly suited for acute pain care. Allosteric modulators can enhance receptor subtype selectivity, offering analgesia with fewer and/or less severe side effects. Neuroinflammation in acute pain is caused by direct insult to the central nervous system and is distinct from neuroinflammation in degenerative disorders. Pharmacologic agents targeting the neuroinflammatory process are limited at this time. Postoperative pain is a prevalent form of acute pain and must be recognized as a global public health challenge. This type of pain may be severe, impede rehabilitation, and is often under-treated. A subset of surgical patients develops chronic postsurgical pain. Acute pain is not just temporally limited pain that often resolves on its own. It is an important subject for further research as acute pain may transition into more damaging and debilitating chronic pain. Reimagining how we treat acute pain will help us better address this urgent unmet medical need.  Cureus 2022-04-09 /pmc/articles/PMC9084930/ /pubmed/35547466 http://dx.doi.org/10.7759/cureus.23992 Text en Copyright © 2022, Castroman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pain Management
Castroman, Pablo
Quiroga, Ovelio
Mayoral Rojals, Victor
Gómez, Maria
Moka, Eleni
Pergolizzi Jr, Joseph
Varrassi, Giustino
Reimagining How We Treat Acute Pain: A Narrative Review
title Reimagining How We Treat Acute Pain: A Narrative Review
title_full Reimagining How We Treat Acute Pain: A Narrative Review
title_fullStr Reimagining How We Treat Acute Pain: A Narrative Review
title_full_unstemmed Reimagining How We Treat Acute Pain: A Narrative Review
title_short Reimagining How We Treat Acute Pain: A Narrative Review
title_sort reimagining how we treat acute pain: a narrative review
topic Pain Management
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084930/
https://www.ncbi.nlm.nih.gov/pubmed/35547466
http://dx.doi.org/10.7759/cureus.23992
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