Novel oligopeptide nanoprobe for targeted cancer cell imaging

Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Wen-Qiang, Qin, Si-Yong, Cheng, Yin-Jia, Ma, Yi-Han, Zhang, Ai-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085486/
https://www.ncbi.nlm.nih.gov/pubmed/35548769
http://dx.doi.org/10.1039/c8ra06034g
_version_ 1784703829307031552
author Ding, Wen-Qiang
Qin, Si-Yong
Cheng, Yin-Jia
Ma, Yi-Han
Zhang, Ai-Qing
author_facet Ding, Wen-Qiang
Qin, Si-Yong
Cheng, Yin-Jia
Ma, Yi-Han
Zhang, Ai-Qing
author_sort Ding, Wen-Qiang
collection PubMed
description Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.
format Online
Article
Text
id pubmed-9085486
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90854862022-05-10 Novel oligopeptide nanoprobe for targeted cancer cell imaging Ding, Wen-Qiang Qin, Si-Yong Cheng, Yin-Jia Ma, Yi-Han Zhang, Ai-Qing RSC Adv Chemistry Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells. The Royal Society of Chemistry 2018-09-03 /pmc/articles/PMC9085486/ /pubmed/35548769 http://dx.doi.org/10.1039/c8ra06034g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ding, Wen-Qiang
Qin, Si-Yong
Cheng, Yin-Jia
Ma, Yi-Han
Zhang, Ai-Qing
Novel oligopeptide nanoprobe for targeted cancer cell imaging
title Novel oligopeptide nanoprobe for targeted cancer cell imaging
title_full Novel oligopeptide nanoprobe for targeted cancer cell imaging
title_fullStr Novel oligopeptide nanoprobe for targeted cancer cell imaging
title_full_unstemmed Novel oligopeptide nanoprobe for targeted cancer cell imaging
title_short Novel oligopeptide nanoprobe for targeted cancer cell imaging
title_sort novel oligopeptide nanoprobe for targeted cancer cell imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085486/
https://www.ncbi.nlm.nih.gov/pubmed/35548769
http://dx.doi.org/10.1039/c8ra06034g
work_keys_str_mv AT dingwenqiang noveloligopeptidenanoprobefortargetedcancercellimaging
AT qinsiyong noveloligopeptidenanoprobefortargetedcancercellimaging
AT chengyinjia noveloligopeptidenanoprobefortargetedcancercellimaging
AT mayihan noveloligopeptidenanoprobefortargetedcancercellimaging
AT zhangaiqing noveloligopeptidenanoprobefortargetedcancercellimaging

Ejemplares similares