A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells

A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes re...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Lv, Huaying, Duan, Guiyun, Dong, Jian, Ge, Yanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085528/
https://www.ncbi.nlm.nih.gov/pubmed/35548712
http://dx.doi.org/10.1039/c8ra06191b
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author Zhang, Ping
Lv, Huaying
Duan, Guiyun
Dong, Jian
Ge, Yanqing
author_facet Zhang, Ping
Lv, Huaying
Duan, Guiyun
Dong, Jian
Ge, Yanqing
author_sort Zhang, Ping
collection PubMed
description A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change.
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spelling pubmed-90855282022-05-10 A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells Zhang, Ping Lv, Huaying Duan, Guiyun Dong, Jian Ge, Yanqing RSC Adv Chemistry A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change. The Royal Society of Chemistry 2018-08-31 /pmc/articles/PMC9085528/ /pubmed/35548712 http://dx.doi.org/10.1039/c8ra06191b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Ping
Lv, Huaying
Duan, Guiyun
Dong, Jian
Ge, Yanqing
A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title_full A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title_fullStr A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title_full_unstemmed A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title_short A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells
title_sort novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect ph in cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085528/
https://www.ncbi.nlm.nih.gov/pubmed/35548712
http://dx.doi.org/10.1039/c8ra06191b
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