Polyellisin, a novel polyketide from cultures of the basidiomycete Polyporus ellisii

Polyellisin (1), an unprecedented polyketide possessing a tricyclic system sharing a spiroketal carbon, was isolated from cultures of the basidiomycete Polyporus ellisii. The structure with absolute configuration was elucidated by means of spectroscopic methods and the single crystal X-ray diffracti...

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Detalles Bibliográficos
Autores principales: Wang, Shuang, Li, Zheng-Hui, Ai, Hong-Lian, He, Juan, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085629/
https://www.ncbi.nlm.nih.gov/pubmed/35548250
http://dx.doi.org/10.1039/c8ra06544f
Descripción
Sumario:Polyellisin (1), an unprecedented polyketide possessing a tricyclic system sharing a spiroketal carbon, was isolated from cultures of the basidiomycete Polyporus ellisii. The structure with absolute configuration was elucidated by means of spectroscopic methods and the single crystal X-ray diffraction. Polyellisin showed NO production inhibition with an IC(50) value of 17.2 μM.

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