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Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to unders...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085871/ https://www.ncbi.nlm.nih.gov/pubmed/35534454 http://dx.doi.org/10.1038/s41467-022-29886-1 |
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author | Valk, Sofie L. Xu, Ting Paquola, Casey Park, Bo-yong Bethlehem, Richard A. I. Vos de Wael, Reinder Royer, Jessica Masouleh, Shahrzad Kharabian Bayrak, Şeyma Kochunov, Peter Yeo, B. T. Thomas Margulies, Daniel Smallwood, Jonathan Eickhoff, Simon B. Bernhardt, Boris C. |
author_facet | Valk, Sofie L. Xu, Ting Paquola, Casey Park, Bo-yong Bethlehem, Richard A. I. Vos de Wael, Reinder Royer, Jessica Masouleh, Shahrzad Kharabian Bayrak, Şeyma Kochunov, Peter Yeo, B. T. Thomas Margulies, Daniel Smallwood, Jonathan Eickhoff, Simon B. Bernhardt, Boris C. |
author_sort | Valk, Sofie L. |
collection | PubMed |
description | Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition. |
format | Online Article Text |
id | pubmed-9085871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90858712022-05-11 Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex Valk, Sofie L. Xu, Ting Paquola, Casey Park, Bo-yong Bethlehem, Richard A. I. Vos de Wael, Reinder Royer, Jessica Masouleh, Shahrzad Kharabian Bayrak, Şeyma Kochunov, Peter Yeo, B. T. Thomas Margulies, Daniel Smallwood, Jonathan Eickhoff, Simon B. Bernhardt, Boris C. Nat Commun Article Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition. Nature Publishing Group UK 2022-05-09 /pmc/articles/PMC9085871/ /pubmed/35534454 http://dx.doi.org/10.1038/s41467-022-29886-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Valk, Sofie L. Xu, Ting Paquola, Casey Park, Bo-yong Bethlehem, Richard A. I. Vos de Wael, Reinder Royer, Jessica Masouleh, Shahrzad Kharabian Bayrak, Şeyma Kochunov, Peter Yeo, B. T. Thomas Margulies, Daniel Smallwood, Jonathan Eickhoff, Simon B. Bernhardt, Boris C. Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title | Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title_full | Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title_fullStr | Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title_full_unstemmed | Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title_short | Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
title_sort | genetic and phylogenetic uncoupling of structure and function in human transmodal cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085871/ https://www.ncbi.nlm.nih.gov/pubmed/35534454 http://dx.doi.org/10.1038/s41467-022-29886-1 |
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