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Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue
Background: Porcine heart and bovine pericardium valves, which are collagen-based with relatively little elastin, have been broadly utilized to construct bioprosthetic heart valves (BHVs). With a larger proportion of elastin, the pulmonary visceral pleura (PVP) has greater elasticity and could poten...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086238/ https://www.ncbi.nlm.nih.gov/pubmed/35557866 http://dx.doi.org/10.3389/fbioe.2022.869095 |
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author | Chen, Ye Lu, Xiao Luo, Haoxiang Kassab, Ghassan S. |
author_facet | Chen, Ye Lu, Xiao Luo, Haoxiang Kassab, Ghassan S. |
author_sort | Chen, Ye |
collection | PubMed |
description | Background: Porcine heart and bovine pericardium valves, which are collagen-based with relatively little elastin, have been broadly utilized to construct bioprosthetic heart valves (BHVs). With a larger proportion of elastin, the pulmonary visceral pleura (PVP) has greater elasticity and could potentially serve as an advantageous biomaterial for the construction/repair of BHVs. The question of how the aortic valve’s performance is affected by its bending rigidity has not been well studied. Methods: Based on the stress–strain relationships of the pericardium and PVP determined by planar uni-axial tests, a three-dimensional (3D) computational fluid–structure interaction (FSI) framework is employed to numerically investigate the aortic valve’s performance by considering three different cases with Young’s modulus as follows: [Formula: see text] , [Formula: see text] , and [Formula: see text] kPa, respectively. Results: The stroke volumes are 112, 99.6, and 91.4 ml as Young’s modulus increases from 375 to 750 and 1500 kPa, respectively. Peak geometric opening area (GOA) values are 2.3, 2.2, and 2.0 cm(2) for [Formula: see text] , 750, and 1500 kPa, respectively. The maximum value of the aortic leaflet stress is about 271 kPa for [Formula: see text] kPa, and it increases to about 383 and 540 kPa for [Formula: see text] and 1500 kPa in the belly region at the peak systole, while it reduces from 550 kPa to 450 and 400 kPa for [Formula: see text] , 750, and 1500 kPa, respectively, at the instant of peak “water-hammer”. Conclusion: A more compliant PVP aortic leaflet valve with a smaller Young’s modulus, [Formula: see text] , has a higher cardiac output, larger GOA, and lower hemodynamic resistance. Most importantly, the aortic leaflet stresses are substantially lower in the belly region within the higher compliance PVP aortic valve tissue during the systole phase, even though some stress increase is also found during the fast-closing phase due to the “water-hammer” effect similar to that in the pericardial tissue. Future clinical studies will be conducted to test the hypothesis that the PVP-based valve leaflets with higher compliance will have lower fatigue or calcification rates due to the overall lower stress. |
format | Online Article Text |
id | pubmed-9086238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90862382022-05-11 Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue Chen, Ye Lu, Xiao Luo, Haoxiang Kassab, Ghassan S. Front Bioeng Biotechnol Bioengineering and Biotechnology Background: Porcine heart and bovine pericardium valves, which are collagen-based with relatively little elastin, have been broadly utilized to construct bioprosthetic heart valves (BHVs). With a larger proportion of elastin, the pulmonary visceral pleura (PVP) has greater elasticity and could potentially serve as an advantageous biomaterial for the construction/repair of BHVs. The question of how the aortic valve’s performance is affected by its bending rigidity has not been well studied. Methods: Based on the stress–strain relationships of the pericardium and PVP determined by planar uni-axial tests, a three-dimensional (3D) computational fluid–structure interaction (FSI) framework is employed to numerically investigate the aortic valve’s performance by considering three different cases with Young’s modulus as follows: [Formula: see text] , [Formula: see text] , and [Formula: see text] kPa, respectively. Results: The stroke volumes are 112, 99.6, and 91.4 ml as Young’s modulus increases from 375 to 750 and 1500 kPa, respectively. Peak geometric opening area (GOA) values are 2.3, 2.2, and 2.0 cm(2) for [Formula: see text] , 750, and 1500 kPa, respectively. The maximum value of the aortic leaflet stress is about 271 kPa for [Formula: see text] kPa, and it increases to about 383 and 540 kPa for [Formula: see text] and 1500 kPa in the belly region at the peak systole, while it reduces from 550 kPa to 450 and 400 kPa for [Formula: see text] , 750, and 1500 kPa, respectively, at the instant of peak “water-hammer”. Conclusion: A more compliant PVP aortic leaflet valve with a smaller Young’s modulus, [Formula: see text] , has a higher cardiac output, larger GOA, and lower hemodynamic resistance. Most importantly, the aortic leaflet stresses are substantially lower in the belly region within the higher compliance PVP aortic valve tissue during the systole phase, even though some stress increase is also found during the fast-closing phase due to the “water-hammer” effect similar to that in the pericardial tissue. Future clinical studies will be conducted to test the hypothesis that the PVP-based valve leaflets with higher compliance will have lower fatigue or calcification rates due to the overall lower stress. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9086238/ /pubmed/35557866 http://dx.doi.org/10.3389/fbioe.2022.869095 Text en Copyright © 2022 Chen, Lu, Luo and Kassab. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Chen, Ye Lu, Xiao Luo, Haoxiang Kassab, Ghassan S. Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title | Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title_full | Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title_fullStr | Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title_full_unstemmed | Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title_short | Aortic Leaflet Stresses Are Substantially Lower Using Pulmonary Visceral Pleura Than Pericardial Tissue |
title_sort | aortic leaflet stresses are substantially lower using pulmonary visceral pleura than pericardial tissue |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086238/ https://www.ncbi.nlm.nih.gov/pubmed/35557866 http://dx.doi.org/10.3389/fbioe.2022.869095 |
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