The Role of T Cells in Ovarian Physiology and Infertility

Infertility affects one in six couples worldwide, with more than 48 million couples affected internationally. The prevalence of infertility is increasing which is thought to be attributed to delayed child-bearing due to socioeconomic factors. Since women are more prone to autoimmune diseases, we sou...

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Autores principales: Knapik, Laura O., Paresh, Shubangi, Nabi, Dalileh, Brayboy, Lynae M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086286/
https://www.ncbi.nlm.nih.gov/pubmed/35557956
http://dx.doi.org/10.3389/fcell.2022.713650
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author Knapik, Laura O.
Paresh, Shubangi
Nabi, Dalileh
Brayboy, Lynae M.
author_facet Knapik, Laura O.
Paresh, Shubangi
Nabi, Dalileh
Brayboy, Lynae M.
author_sort Knapik, Laura O.
collection PubMed
description Infertility affects one in six couples worldwide, with more than 48 million couples affected internationally. The prevalence of infertility is increasing which is thought to be attributed to delayed child-bearing due to socioeconomic factors. Since women are more prone to autoimmune diseases, we sought to describe the correlation between ovarian-mediated infertility and autoimmunity, and more specifically, the role of T cells in infertility. T cells prevent autoimmune diseases and allow maternal immune tolerance of the semi-allogeneic fetus during pregnancy. However, the role of T cells in ovarian physiology has yet to be fully understood.
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spelling pubmed-90862862022-05-11 The Role of T Cells in Ovarian Physiology and Infertility Knapik, Laura O. Paresh, Shubangi Nabi, Dalileh Brayboy, Lynae M. Front Cell Dev Biol Cell and Developmental Biology Infertility affects one in six couples worldwide, with more than 48 million couples affected internationally. The prevalence of infertility is increasing which is thought to be attributed to delayed child-bearing due to socioeconomic factors. Since women are more prone to autoimmune diseases, we sought to describe the correlation between ovarian-mediated infertility and autoimmunity, and more specifically, the role of T cells in infertility. T cells prevent autoimmune diseases and allow maternal immune tolerance of the semi-allogeneic fetus during pregnancy. However, the role of T cells in ovarian physiology has yet to be fully understood. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9086286/ /pubmed/35557956 http://dx.doi.org/10.3389/fcell.2022.713650 Text en Copyright © 2022 Knapik, Paresh, Nabi and Brayboy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Knapik, Laura O.
Paresh, Shubangi
Nabi, Dalileh
Brayboy, Lynae M.
The Role of T Cells in Ovarian Physiology and Infertility
title The Role of T Cells in Ovarian Physiology and Infertility
title_full The Role of T Cells in Ovarian Physiology and Infertility
title_fullStr The Role of T Cells in Ovarian Physiology and Infertility
title_full_unstemmed The Role of T Cells in Ovarian Physiology and Infertility
title_short The Role of T Cells in Ovarian Physiology and Infertility
title_sort role of t cells in ovarian physiology and infertility
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086286/
https://www.ncbi.nlm.nih.gov/pubmed/35557956
http://dx.doi.org/10.3389/fcell.2022.713650
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