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Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia. Vesicular glutamate transporter 2 (VGluT2) accumulates glutamate into synaptic vesicles and plays multiple roles in the central nervous...

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Detalles Bibliográficos
Autores principales:	He, Liqiong, Xu, Wei, Zhang, Chengliang, Ding, Zhuofeng, Guo, Qulian, Zou, Wangyuan, Wang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086316/ https://www.ncbi.nlm.nih.gov/pubmed/35559256 http://dx.doi.org/10.3389/fphar.2022.861786

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