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Antidepressant activity of an aqueous extract from okra seeds
Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086372/ https://www.ncbi.nlm.nih.gov/pubmed/35547711 http://dx.doi.org/10.1039/c8ra03201g |
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author | Xia, Fangbo Li, Chenchen Li, Mengqiu Liao, Yonghong Liu, Xinmin Si, Jianyong Chang, Qi Pan, Ruile |
author_facet | Xia, Fangbo Li, Chenchen Li, Mengqiu Liao, Yonghong Liu, Xinmin Si, Jianyong Chang, Qi Pan, Ruile |
author_sort | Xia, Fangbo |
collection | PubMed |
description | Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluated with behavioral tests including an open field test, tail suspension test (TST), forced-swimming test (FST) and novelty suppressed feeding test (NSFT) for sub-chronic treatment and chronic sleep-interruption (CSI) animal models. The chemical constituents of OSE were identified by using UPLC-DAD/Q-TOF MS. To investigate the mechanism, the prefrontal cortex and hippocampus were collected to determine neurotransmitters, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA). Blood serum was prepared for the determination of corticosterone (CORT) and adrenocorticotropic hormone (ACTH). Results demonstrated that OSE possessed an antidepressant effect in both sub-chronic treatment and CSI animal models through suppressing the hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis, alleviating oxidative stress and regulating neurotransmitter levels in the hippocampus and frontal cortex. Besides, chemical analysis based on the UPLC-DAD/ESI-Q-TOF MS approach showed that OSE mainly contained catechin and quercetin derivatives. The present study provided a scientific basis for developing okra seeds to be a dietary supplement for MDD prevention. |
format | Online Article Text |
id | pubmed-9086372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90863722022-05-10 Antidepressant activity of an aqueous extract from okra seeds Xia, Fangbo Li, Chenchen Li, Mengqiu Liao, Yonghong Liu, Xinmin Si, Jianyong Chang, Qi Pan, Ruile RSC Adv Chemistry Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluated with behavioral tests including an open field test, tail suspension test (TST), forced-swimming test (FST) and novelty suppressed feeding test (NSFT) for sub-chronic treatment and chronic sleep-interruption (CSI) animal models. The chemical constituents of OSE were identified by using UPLC-DAD/Q-TOF MS. To investigate the mechanism, the prefrontal cortex and hippocampus were collected to determine neurotransmitters, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA). Blood serum was prepared for the determination of corticosterone (CORT) and adrenocorticotropic hormone (ACTH). Results demonstrated that OSE possessed an antidepressant effect in both sub-chronic treatment and CSI animal models through suppressing the hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis, alleviating oxidative stress and regulating neurotransmitter levels in the hippocampus and frontal cortex. Besides, chemical analysis based on the UPLC-DAD/ESI-Q-TOF MS approach showed that OSE mainly contained catechin and quercetin derivatives. The present study provided a scientific basis for developing okra seeds to be a dietary supplement for MDD prevention. The Royal Society of Chemistry 2018-09-21 /pmc/articles/PMC9086372/ /pubmed/35547711 http://dx.doi.org/10.1039/c8ra03201g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Xia, Fangbo Li, Chenchen Li, Mengqiu Liao, Yonghong Liu, Xinmin Si, Jianyong Chang, Qi Pan, Ruile Antidepressant activity of an aqueous extract from okra seeds |
title | Antidepressant activity of an aqueous extract from okra seeds |
title_full | Antidepressant activity of an aqueous extract from okra seeds |
title_fullStr | Antidepressant activity of an aqueous extract from okra seeds |
title_full_unstemmed | Antidepressant activity of an aqueous extract from okra seeds |
title_short | Antidepressant activity of an aqueous extract from okra seeds |
title_sort | antidepressant activity of an aqueous extract from okra seeds |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086372/ https://www.ncbi.nlm.nih.gov/pubmed/35547711 http://dx.doi.org/10.1039/c8ra03201g |
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