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Antidepressant activity of an aqueous extract from okra seeds

Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluat...

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Autores principales: Xia, Fangbo, Li, Chenchen, Li, Mengqiu, Liao, Yonghong, Liu, Xinmin, Si, Jianyong, Chang, Qi, Pan, Ruile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086372/
https://www.ncbi.nlm.nih.gov/pubmed/35547711
http://dx.doi.org/10.1039/c8ra03201g
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author Xia, Fangbo
Li, Chenchen
Li, Mengqiu
Liao, Yonghong
Liu, Xinmin
Si, Jianyong
Chang, Qi
Pan, Ruile
author_facet Xia, Fangbo
Li, Chenchen
Li, Mengqiu
Liao, Yonghong
Liu, Xinmin
Si, Jianyong
Chang, Qi
Pan, Ruile
author_sort Xia, Fangbo
collection PubMed
description Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluated with behavioral tests including an open field test, tail suspension test (TST), forced-swimming test (FST) and novelty suppressed feeding test (NSFT) for sub-chronic treatment and chronic sleep-interruption (CSI) animal models. The chemical constituents of OSE were identified by using UPLC-DAD/Q-TOF MS. To investigate the mechanism, the prefrontal cortex and hippocampus were collected to determine neurotransmitters, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA). Blood serum was prepared for the determination of corticosterone (CORT) and adrenocorticotropic hormone (ACTH). Results demonstrated that OSE possessed an antidepressant effect in both sub-chronic treatment and CSI animal models through suppressing the hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis, alleviating oxidative stress and regulating neurotransmitter levels in the hippocampus and frontal cortex. Besides, chemical analysis based on the UPLC-DAD/ESI-Q-TOF MS approach showed that OSE mainly contained catechin and quercetin derivatives. The present study provided a scientific basis for developing okra seeds to be a dietary supplement for MDD prevention.
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spelling pubmed-90863722022-05-10 Antidepressant activity of an aqueous extract from okra seeds Xia, Fangbo Li, Chenchen Li, Mengqiu Liao, Yonghong Liu, Xinmin Si, Jianyong Chang, Qi Pan, Ruile RSC Adv Chemistry Faced with the increasing incidence of major depression disorder (MDD) and the unsatisfactory effect of current drugs, there has been growing attention on the relation between dietary supplements and MDD prevention. In this research, the antidepressant activity of okra seed extract (OSE) was evaluated with behavioral tests including an open field test, tail suspension test (TST), forced-swimming test (FST) and novelty suppressed feeding test (NSFT) for sub-chronic treatment and chronic sleep-interruption (CSI) animal models. The chemical constituents of OSE were identified by using UPLC-DAD/Q-TOF MS. To investigate the mechanism, the prefrontal cortex and hippocampus were collected to determine neurotransmitters, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA). Blood serum was prepared for the determination of corticosterone (CORT) and adrenocorticotropic hormone (ACTH). Results demonstrated that OSE possessed an antidepressant effect in both sub-chronic treatment and CSI animal models through suppressing the hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis, alleviating oxidative stress and regulating neurotransmitter levels in the hippocampus and frontal cortex. Besides, chemical analysis based on the UPLC-DAD/ESI-Q-TOF MS approach showed that OSE mainly contained catechin and quercetin derivatives. The present study provided a scientific basis for developing okra seeds to be a dietary supplement for MDD prevention. The Royal Society of Chemistry 2018-09-21 /pmc/articles/PMC9086372/ /pubmed/35547711 http://dx.doi.org/10.1039/c8ra03201g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Xia, Fangbo
Li, Chenchen
Li, Mengqiu
Liao, Yonghong
Liu, Xinmin
Si, Jianyong
Chang, Qi
Pan, Ruile
Antidepressant activity of an aqueous extract from okra seeds
title Antidepressant activity of an aqueous extract from okra seeds
title_full Antidepressant activity of an aqueous extract from okra seeds
title_fullStr Antidepressant activity of an aqueous extract from okra seeds
title_full_unstemmed Antidepressant activity of an aqueous extract from okra seeds
title_short Antidepressant activity of an aqueous extract from okra seeds
title_sort antidepressant activity of an aqueous extract from okra seeds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086372/
https://www.ncbi.nlm.nih.gov/pubmed/35547711
http://dx.doi.org/10.1039/c8ra03201g
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