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Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086375/ https://www.ncbi.nlm.nih.gov/pubmed/35547689 http://dx.doi.org/10.1039/c8ra06479b |
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author | Megarajan, Sengan Subramaniyan, Siva Bala Muthuswamy, Sureshan Anthony, Savarimuthu Philip Arunachalam, Jothi Moon, Dohyun Veerappan, Anbazhagan |
author_facet | Megarajan, Sengan Subramaniyan, Siva Bala Muthuswamy, Sureshan Anthony, Savarimuthu Philip Arunachalam, Jothi Moon, Dohyun Veerappan, Anbazhagan |
author_sort | Megarajan, Sengan |
collection | PubMed |
description | Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B. |
format | Online Article Text |
id | pubmed-9086375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90863752022-05-10 Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane Megarajan, Sengan Subramaniyan, Siva Bala Muthuswamy, Sureshan Anthony, Savarimuthu Philip Arunachalam, Jothi Moon, Dohyun Veerappan, Anbazhagan RSC Adv Chemistry Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B. The Royal Society of Chemistry 2018-09-21 /pmc/articles/PMC9086375/ /pubmed/35547689 http://dx.doi.org/10.1039/c8ra06479b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Megarajan, Sengan Subramaniyan, Siva Bala Muthuswamy, Sureshan Anthony, Savarimuthu Philip Arunachalam, Jothi Moon, Dohyun Veerappan, Anbazhagan Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title | Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title_full | Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title_fullStr | Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title_full_unstemmed | Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title_short | Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
title_sort | synthesis, supramolecular organization and thermotropic phase behaviour of n-acyltris(hydroxymethyl)aminomethane |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086375/ https://www.ncbi.nlm.nih.gov/pubmed/35547689 http://dx.doi.org/10.1039/c8ra06479b |
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