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Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropi...

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Autores principales: Megarajan, Sengan, Subramaniyan, Siva Bala, Muthuswamy, Sureshan, Anthony, Savarimuthu Philip, Arunachalam, Jothi, Moon, Dohyun, Veerappan, Anbazhagan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086375/
https://www.ncbi.nlm.nih.gov/pubmed/35547689
http://dx.doi.org/10.1039/c8ra06479b
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author Megarajan, Sengan
Subramaniyan, Siva Bala
Muthuswamy, Sureshan
Anthony, Savarimuthu Philip
Arunachalam, Jothi
Moon, Dohyun
Veerappan, Anbazhagan
author_facet Megarajan, Sengan
Subramaniyan, Siva Bala
Muthuswamy, Sureshan
Anthony, Savarimuthu Philip
Arunachalam, Jothi
Moon, Dohyun
Veerappan, Anbazhagan
author_sort Megarajan, Sengan
collection PubMed
description Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B.
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spelling pubmed-90863752022-05-10 Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane Megarajan, Sengan Subramaniyan, Siva Bala Muthuswamy, Sureshan Anthony, Savarimuthu Philip Arunachalam, Jothi Moon, Dohyun Veerappan, Anbazhagan RSC Adv Chemistry Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B. The Royal Society of Chemistry 2018-09-21 /pmc/articles/PMC9086375/ /pubmed/35547689 http://dx.doi.org/10.1039/c8ra06479b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Megarajan, Sengan
Subramaniyan, Siva Bala
Muthuswamy, Sureshan
Anthony, Savarimuthu Philip
Arunachalam, Jothi
Moon, Dohyun
Veerappan, Anbazhagan
Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title_full Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title_fullStr Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title_full_unstemmed Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title_short Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
title_sort synthesis, supramolecular organization and thermotropic phase behaviour of n-acyltris(hydroxymethyl)aminomethane
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086375/
https://www.ncbi.nlm.nih.gov/pubmed/35547689
http://dx.doi.org/10.1039/c8ra06479b
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