The CRISPR-Cas9 system: a promising tool for discovering potential approaches to overcome drug resistance in cancer

The CRISPR-Cas system was identified in bacteria as an immune defense mechanism against threats from the external environment. A common form of this system, called CRISPR-Cas9, is now widely used in gene editing, especially in mammalian cells. Through CRISPR-Cas9, gene knock-ins or knock-outs have b...

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Detalles Bibliográficos
Autores principales: Zhang, Jiayu, Zhou, Wenlong, Wang, Xiaoxuan, Wang, Lihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086466/
https://www.ncbi.nlm.nih.gov/pubmed/35548117
http://dx.doi.org/10.1039/c8ra04509g
Descripción
Sumario:The CRISPR-Cas system was identified in bacteria as an immune defense mechanism against threats from the external environment. A common form of this system, called CRISPR-Cas9, is now widely used in gene editing, especially in mammalian cells. Through CRISPR-Cas9, gene knock-ins or knock-outs have become more feasible, thus deepening our understanding of the mechanisms of human diseases, including cancers, and suggesting possible treatment strategies. In this review, we discuss how CRISPR-Cas9 can be used as a tool to discover more about drug-resistance in cancers, including both the underlying mechanisms and ways to overcome them.

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