Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering

The double-stranded RNA sensor kinase PKR is one of four integrated stress response (ISR) sensor kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α) in response to stress. The current model of PKR activation considers the formation of back-to-back PKR dimers as a prere...

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Detalles Bibliográficos
Autores principales: Zappa, Francesca, Muniozguren, Nerea L., Wilson, Maxwell Z., Costello, Michael S., Ponce-Rojas, Jose Carlos, Acosta-Alvear, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086502/
https://www.ncbi.nlm.nih.gov/pubmed/35522180
http://dx.doi.org/10.1083/jcb.202111100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086502/
https://www.ncbi.nlm.nih.gov/pubmed/35522180
http://dx.doi.org/10.1083/jcb.202111100

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