Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides

Efficient and divergent one-pot synthesis of polyfunctionalized 2-pyridones from β-keto amides based on reaction condition selection was developed. The methodology offers several significant advantages including mild conditions, ease of handling, high yields, and a relatively broad range of substrat...

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Detalles Bibliográficos
Autores principales: Gao, Baochang, Sun, Yufeng, Wang, Jun, Yuan, Zhigang, Zu, Liwu, Zhang, Xu, Liu, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086556/
https://www.ncbi.nlm.nih.gov/pubmed/35548816
http://dx.doi.org/10.1039/c8ra05709e
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author Gao, Baochang
Sun, Yufeng
Wang, Jun
Yuan, Zhigang
Zu, Liwu
Zhang, Xu
Liu, Wenbin
author_facet Gao, Baochang
Sun, Yufeng
Wang, Jun
Yuan, Zhigang
Zu, Liwu
Zhang, Xu
Liu, Wenbin
author_sort Gao, Baochang
collection PubMed
description Efficient and divergent one-pot synthesis of polyfunctionalized 2-pyridones from β-keto amides based on reaction condition selection was developed. The methodology offers several significant advantages including mild conditions, ease of handling, high yields, and a relatively broad range of substrates. Based on various experiments and observations, a plausible mechanism for the selective synthesis of 2-pyridones was proposed.
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spelling pubmed-90865562022-05-10 Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides Gao, Baochang Sun, Yufeng Wang, Jun Yuan, Zhigang Zu, Liwu Zhang, Xu Liu, Wenbin RSC Adv Chemistry Efficient and divergent one-pot synthesis of polyfunctionalized 2-pyridones from β-keto amides based on reaction condition selection was developed. The methodology offers several significant advantages including mild conditions, ease of handling, high yields, and a relatively broad range of substrates. Based on various experiments and observations, a plausible mechanism for the selective synthesis of 2-pyridones was proposed. The Royal Society of Chemistry 2018-10-01 /pmc/articles/PMC9086556/ /pubmed/35548816 http://dx.doi.org/10.1039/c8ra05709e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Gao, Baochang
Sun, Yufeng
Wang, Jun
Yuan, Zhigang
Zu, Liwu
Zhang, Xu
Liu, Wenbin
Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title_full Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title_fullStr Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title_full_unstemmed Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title_short Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
title_sort efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086556/
https://www.ncbi.nlm.nih.gov/pubmed/35548816
http://dx.doi.org/10.1039/c8ra05709e
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