Reducing exacerbations in children and adults with primary ciliary dyskinesia using erdosteine and/or azithromycin therapy (REPEAT trial): study protocol for a multicentre, double-blind, double-dummy, 2×2 partial factorial, randomised controlled trial

INTRODUCTION: Primary ciliary dyskinesia (PCD) is a rare, progressive, inherited ciliopathic disorder, which is incurable and frequently complicated by the development of bronchiectasis. There are few randomised controlled trials (RCTs) involving children and adults with PCD and thus evidence of eff...

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Autores principales: Chang, Anne B, Morgan, Lucy C, Duncan, Emma L, Chatfield, Mark D, Schultz, André, Leo, Paul J, McCallum, Gabrielle B, McInerney-Leo, Aideen M, McPhail, Steven M, Zhao, Yuejen, Kruljac, Catherine, Smith-Vaughan, Heidi C, Morris, Peter S, Marchant, Julie M, Yerkovich, Stephanie T, Cook, Anne L, Wurzel, Danielle, Versteegh, Lesley, O’Farrell, Hannah, McElrea, Margaret S, Fletcher, Sabine, D'Antoine, Heather, Stroil-Salama, Enna, Robinson, Phil J, Grimwood, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Orphan Lung Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086630/
https://www.ncbi.nlm.nih.gov/pubmed/35534039
http://dx.doi.org/10.1136/bmjresp-2022-001236

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