Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter

A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities.

Detalles Bibliográficos
Autores principales: Zhu, Xiao-Yu, Lv, Mei-Heng, Zhao, Ya-Nan, Lan, Li-Yan, Li, Wen-Ze, Xiao, Lin-Jiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086683/
https://www.ncbi.nlm.nih.gov/pubmed/35548804
http://dx.doi.org/10.1039/c8ra04325f
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author Zhu, Xiao-Yu
Lv, Mei-Heng
Zhao, Ya-Nan
Lan, Li-Yan
Li, Wen-Ze
Xiao, Lin-Jiu
author_facet Zhu, Xiao-Yu
Lv, Mei-Heng
Zhao, Ya-Nan
Lan, Li-Yan
Li, Wen-Ze
Xiao, Lin-Jiu
author_sort Zhu, Xiao-Yu
collection PubMed
description A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities.
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spelling pubmed-90866832022-05-10 Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter Zhu, Xiao-Yu Lv, Mei-Heng Zhao, Ya-Nan Lan, Li-Yan Li, Wen-Ze Xiao, Lin-Jiu RSC Adv Chemistry A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities. The Royal Society of Chemistry 2018-10-03 /pmc/articles/PMC9086683/ /pubmed/35548804 http://dx.doi.org/10.1039/c8ra04325f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhu, Xiao-Yu
Lv, Mei-Heng
Zhao, Ya-Nan
Lan, Li-Yan
Li, Wen-Ze
Xiao, Lin-Jiu
Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title_full Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title_fullStr Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title_full_unstemmed Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title_short Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
title_sort organocatalytic sulfa-michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086683/
https://www.ncbi.nlm.nih.gov/pubmed/35548804
http://dx.doi.org/10.1039/c8ra04325f
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