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Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications
In this systematic review, we aim to describe the association between temporal lobe epilepsy (TLE) and sleep, with bidirectional links in mechanisms and therapeutic aspects. Sleep stages may variably impact seizure occurrence, secondary generalization and the development, frequency and distribution...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086778/ https://www.ncbi.nlm.nih.gov/pubmed/35558736 http://dx.doi.org/10.3389/fnhum.2022.849899 |
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author | Garg, Divyani Charlesworth, Laurel Shukla, Garima |
author_facet | Garg, Divyani Charlesworth, Laurel Shukla, Garima |
author_sort | Garg, Divyani |
collection | PubMed |
description | In this systematic review, we aim to describe the association between temporal lobe epilepsy (TLE) and sleep, with bidirectional links in mechanisms and therapeutic aspects. Sleep stages may variably impact seizure occurrence, secondary generalization and the development, frequency and distribution of interictal epileptiform discharges. Conversely, epilepsy affects sleep micro- and macroarchitecture. TLE, the most frequent form of drug resistant epilepsy (DRE), shares an enduring relationship with sleep, with some intriguing potential mechanisms specific to anatomic localization, linking the two. Sleep characteristics of TLE may also inform localizing properties in persons with DRE, since seizures arising from the temporal lobe seem to be more common during wakefulness, compared to seizures of extratemporal origin. Polysomnographic studies indicate that persons with TLE may experience excessive daytime somnolence, disrupted sleep architecture, increased wake after sleep onset, frequent shifts in sleep stages, lower sleep efficiency, decreased rapid eye movement (REM) sleep, and possibly, increased incidence of sleep apnea. Limited literature suggests that effective epilepsy surgery may remedy many of these objective and subjective sleep-related concerns, via multipronged effects, apart from reduced seizure frequency. Additionally, sleep abnormalities also seem to influence memory, language and cognitive-executive function in both medically controlled and refractory TLE. Another aspect of the relationship pertains to anti-seizure medications (ASMs), which may contribute significantly to sleep characteristics and abnormalities in persons with TLE. Literature focused on specific aspects of TLE and sleep is limited, and heterogeneous. Future investigations are essential to understand the pathogenetic mechanisms linking sleep abnormalities on epilepsy outcomes in the important sub-population of TLE. |
format | Online Article Text |
id | pubmed-9086778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90867782022-05-11 Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications Garg, Divyani Charlesworth, Laurel Shukla, Garima Front Hum Neurosci Neuroscience In this systematic review, we aim to describe the association between temporal lobe epilepsy (TLE) and sleep, with bidirectional links in mechanisms and therapeutic aspects. Sleep stages may variably impact seizure occurrence, secondary generalization and the development, frequency and distribution of interictal epileptiform discharges. Conversely, epilepsy affects sleep micro- and macroarchitecture. TLE, the most frequent form of drug resistant epilepsy (DRE), shares an enduring relationship with sleep, with some intriguing potential mechanisms specific to anatomic localization, linking the two. Sleep characteristics of TLE may also inform localizing properties in persons with DRE, since seizures arising from the temporal lobe seem to be more common during wakefulness, compared to seizures of extratemporal origin. Polysomnographic studies indicate that persons with TLE may experience excessive daytime somnolence, disrupted sleep architecture, increased wake after sleep onset, frequent shifts in sleep stages, lower sleep efficiency, decreased rapid eye movement (REM) sleep, and possibly, increased incidence of sleep apnea. Limited literature suggests that effective epilepsy surgery may remedy many of these objective and subjective sleep-related concerns, via multipronged effects, apart from reduced seizure frequency. Additionally, sleep abnormalities also seem to influence memory, language and cognitive-executive function in both medically controlled and refractory TLE. Another aspect of the relationship pertains to anti-seizure medications (ASMs), which may contribute significantly to sleep characteristics and abnormalities in persons with TLE. Literature focused on specific aspects of TLE and sleep is limited, and heterogeneous. Future investigations are essential to understand the pathogenetic mechanisms linking sleep abnormalities on epilepsy outcomes in the important sub-population of TLE. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9086778/ /pubmed/35558736 http://dx.doi.org/10.3389/fnhum.2022.849899 Text en Copyright © 2022 Garg, Charlesworth and Shukla. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Garg, Divyani Charlesworth, Laurel Shukla, Garima Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title | Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title_full | Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title_fullStr | Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title_full_unstemmed | Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title_short | Sleep and Temporal Lobe Epilepsy – Associations, Mechanisms and Treatment Implications |
title_sort | sleep and temporal lobe epilepsy – associations, mechanisms and treatment implications |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086778/ https://www.ncbi.nlm.nih.gov/pubmed/35558736 http://dx.doi.org/10.3389/fnhum.2022.849899 |
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