A Polygenic Score for Type 2 Diabetes Improves Risk Stratification Beyond Current Clinical Screening Factors in an Ancestrally Diverse Sample

A substantial proportion of the adult United States population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS)...

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Detalles Bibliográficos
Autores principales: Ashenhurst, James R., Sazonova, Olga V., Svrchek, Olivia, Detweiler, Stacey, Kita, Ryosuke, Babalola, Liz, McIntyre, Matthew, Aslibekyan, Stella, Fontanillas, Pierre, Shringarpure, Suyash, Pollard, Jeffrey D., Koelsch, Bertram L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086969/
https://www.ncbi.nlm.nih.gov/pubmed/35559025
http://dx.doi.org/10.3389/fgene.2022.871260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086969/
https://www.ncbi.nlm.nih.gov/pubmed/35559025
http://dx.doi.org/10.3389/fgene.2022.871260

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