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Felt Stigma and Its Underlying Contributors in Epilepsy Patients

OBJECTIVE: To explore the correlated clinical and psychological factors of stigmatization and investigate the relationship between stigma and white matter abnormalities in epilepsy patients. METHODS: Stigmatization was obtained by a three-item stigma scale in 256 epilepsy patients with genetic or un...

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Autores principales: Mao, Lingyan, Wang, Keying, Zhang, Qianqian, Wang, Jing, Zhao, Yanan, Peng, Weifeng, Ding, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087196/
https://www.ncbi.nlm.nih.gov/pubmed/35558541
http://dx.doi.org/10.3389/fpubh.2022.879895
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author Mao, Lingyan
Wang, Keying
Zhang, Qianqian
Wang, Jing
Zhao, Yanan
Peng, Weifeng
Ding, Jing
author_facet Mao, Lingyan
Wang, Keying
Zhang, Qianqian
Wang, Jing
Zhao, Yanan
Peng, Weifeng
Ding, Jing
author_sort Mao, Lingyan
collection PubMed
description OBJECTIVE: To explore the correlated clinical and psychological factors of stigmatization and investigate the relationship between stigma and white matter abnormalities in epilepsy patients. METHODS: Stigmatization was obtained by a three-item stigma scale in 256 epilepsy patients with genetic or unknown etiology. Personality and quality of life (QOL) were assessed by Eysenck Personality Questionnaire (EPQ) and QOL-31 questionnaire respectively. One hundred and fourteen of them were performed Hamilton Depression Scale-17 (HAMD) and scanned with diffusion tensor imaging in 3T MRI. Fractional anisotropy (FA) values of frontotemporal contact fibers were calculated. RESULTS: There were about 39.8% patients felt stigma, with the highest score (Score 3) in 8.2% (21/256). Stigma scores were significantly negatively correlated with education (P < 0.01), age of onset (P < 0.05), extraversion score of EPQ (P < 0.01), total and all the subscale QOL scores (P < 0.001), and positively correlated with duration (P < 0.01), HAMD score (P < 0.001), neuroticism score of EPQ (P < 0.001). We found negative correlation between stigma scores and FA values of right superior longitudinal fasciculus and left cingulum (P < 0.05). Logistic regression results showed that FA value of left cingulum (P = 0.011; OR = 0.000), social function (P = 0.000; OR = 0.935) of QOL, and neuroticism score of EPQ (P = 0.033; OR = 1.123) independently correlated to felt stigma. CONCLUSION: Felt stigma in epilepsy patients was found to be correlated with neuroticism, depression, and deficient social function of QOL, which might be predisposed by the impairment of the left cingulum. Our results provide preliminary evidence for the underlying neural circuits in stigmatization.
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spelling pubmed-90871962022-05-11 Felt Stigma and Its Underlying Contributors in Epilepsy Patients Mao, Lingyan Wang, Keying Zhang, Qianqian Wang, Jing Zhao, Yanan Peng, Weifeng Ding, Jing Front Public Health Public Health OBJECTIVE: To explore the correlated clinical and psychological factors of stigmatization and investigate the relationship between stigma and white matter abnormalities in epilepsy patients. METHODS: Stigmatization was obtained by a three-item stigma scale in 256 epilepsy patients with genetic or unknown etiology. Personality and quality of life (QOL) were assessed by Eysenck Personality Questionnaire (EPQ) and QOL-31 questionnaire respectively. One hundred and fourteen of them were performed Hamilton Depression Scale-17 (HAMD) and scanned with diffusion tensor imaging in 3T MRI. Fractional anisotropy (FA) values of frontotemporal contact fibers were calculated. RESULTS: There were about 39.8% patients felt stigma, with the highest score (Score 3) in 8.2% (21/256). Stigma scores were significantly negatively correlated with education (P < 0.01), age of onset (P < 0.05), extraversion score of EPQ (P < 0.01), total and all the subscale QOL scores (P < 0.001), and positively correlated with duration (P < 0.01), HAMD score (P < 0.001), neuroticism score of EPQ (P < 0.001). We found negative correlation between stigma scores and FA values of right superior longitudinal fasciculus and left cingulum (P < 0.05). Logistic regression results showed that FA value of left cingulum (P = 0.011; OR = 0.000), social function (P = 0.000; OR = 0.935) of QOL, and neuroticism score of EPQ (P = 0.033; OR = 1.123) independently correlated to felt stigma. CONCLUSION: Felt stigma in epilepsy patients was found to be correlated with neuroticism, depression, and deficient social function of QOL, which might be predisposed by the impairment of the left cingulum. Our results provide preliminary evidence for the underlying neural circuits in stigmatization. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9087196/ /pubmed/35558541 http://dx.doi.org/10.3389/fpubh.2022.879895 Text en Copyright © 2022 Mao, Wang, Zhang, Wang, Zhao, Peng and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Mao, Lingyan
Wang, Keying
Zhang, Qianqian
Wang, Jing
Zhao, Yanan
Peng, Weifeng
Ding, Jing
Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title_full Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title_fullStr Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title_full_unstemmed Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title_short Felt Stigma and Its Underlying Contributors in Epilepsy Patients
title_sort felt stigma and its underlying contributors in epilepsy patients
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087196/
https://www.ncbi.nlm.nih.gov/pubmed/35558541
http://dx.doi.org/10.3389/fpubh.2022.879895
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