Cargando…

Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway

OBJECTIVE: To investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer and activator of transcription 3 (STAT3) signalling in gastric cancer cell lines. METHODS: In vivo tumour xenograft anticancer assays were undertaken to confirm the anticancer activity of PL. Cell vi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Di, Wei, Xinyue, Yang, Ke, Liu, Xinyue, Song, Yujin, Bai, Futing, Jiang, Yi, Guo, Yuhang, Jha, Rajiv Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Pre-Clinical Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087272/ https://www.ncbi.nlm.nih.gov/pubmed/35481419 http://dx.doi.org/10.1177/03000605221093308

Ejemplares similares

Piperlongumine increases the sensitivity of bladder cancer to cisplatin by mitochondrial ROS
por: Pan, Xiaobo, et al.
Publicado: (2022)

Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer
por: Zou, Peng, et al.
Publicado: (2015)

Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells
por: Qiu, Chenyu, et al.
Publicado: (2023)

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation
por: Sun, Ai-Ling, et al.
Publicado: (2021)

Preformulation Studies on Piperlongumine
por: Aodah, Alhassan, et al.
Publicado: (2016)

DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER
por: Bharadwaj, Uddalak, et al.
Publicado: (2014)

Metabolic profile and safety of piperlongumine
por: de Lima Moreira, Fernanda, et al.
Publicado: (2016)

Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells
por: Yao, Yao, et al.
Publicado: (2016)

Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
por: Liu, Qian Rong, et al.
Publicado: (2014)

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
por: Chen, Yong, et al.
Publicado: (2015)

Antimicrobial and Synergistic Effects of Commercial Piperine and Piperlongumine in Combination with Conventional Antimicrobials
por: Mgbeahuruike, Eunice Ego, et al.
Publicado: (2019)

Identification of Piperlongumine as Potent Inhibitor of Necroptosis
por: He, Xiaoyan, et al.
Publicado: (2023)

Piperlongumine Induces Cellular Apoptosis and Autophagy via the ROS/Akt Signaling Pathway in Human Follicular Thyroid Cancer Cells
por: Lin, Tsung-Hsing, et al.
Publicado: (2023)

The anti-alcohol dependency drug disulfiram inhibits the viability and progression of gastric cancer cells by regulating the Wnt and NF-κB pathways
por: Zhang, Jun, et al.
Publicado: (2020)

Piperlongumine-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane
por: Bissinger, Rosi, et al.
Publicado: (2014)

Survivin Promotes Piperlongumine Resistance in Ovarian Cancer
por: Nan, Xing-Wei, et al.
Publicado: (2019)

Piperlongumine promotes death of retinoblastoma cancer cells
por: Allaman-Pillet, Nathalie, et al.
Publicado: (2021)

The promising potential of piperlongumine as an emerging therapeutics for cancer
por: Parama, Dey, et al.
Publicado: (2021)

RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells
por: Patel, Hima, et al.
Publicado: (2023)

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
por: Zhang, Qianqian, et al.
Publicado: (2019)

The top 100 most impactful articles and recent trends in nasopharyngeal carcinoma from 1970 to 2018: a bibliometric analysis
por: Wu, QingWu, et al.
Publicado: (2020)

Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways
por: Liu, Xuan, et al.
Publicado: (2022)

Nelfinavir restricts A549 cell growth by inhibiting STAT3 signaling
por: He, Fangli, et al.
Publicado: (2021)

Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)
por: Yuan, Hengjie, et al.
Publicado: (2015)

Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer
por: Chen, Di, et al.
Publicado: (2019)

Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain
por: Yadav, Vaishali, et al.
Publicado: (2015)

ADAR1 affects gastric cancer cell metastasis and reverses cisplatin resistance through AZIN1
por: Wang, Honghong, et al.
Publicado: (2023)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
por: Conde, João, et al.
Publicado: (2021)

Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer Cells via ROS Regulation
por: Zhang, Chao, et al.
Publicado: (2019)

Corrigendum: Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
por: Zhang, Qianqian, et al.
Publicado: (2022)

Piperlongumine induces autophagy by targeting p38 signaling
por: Wang, Y, et al.
Publicado: (2013)

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
por: Bullova, Petra, et al.
Publicado: (2016)

Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
por: Henrique, Tiago, et al.
Publicado: (2020)

Piperlongumine Is an NLRP3 Inhibitor With Anti-inflammatory Activity
por: Shi, Jie, et al.
Publicado: (2022)

Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species(†)
por: Yuan, Hengjie, et al.
Publicado: (2016)

Combined treatment with a gastric inhibitory polypeptide receptor antagonist and a peptidyl peptidase-4 inhibitor improves metabolic abnormalities in diabetic mice
por: Yang, Fei, et al.
Publicado: (2021)

L'Europe aura en 1958 son laboratoire "atomique" pour 6 milliards. Il sera édifié á Geneve
Publicado: (1951)

Europe laboratory may get five-billion-volt cyclotron
por: Humphreys, W J
Publicado: (1951)

A la conférence atomique européenne l'Angleterre propose d'installer à Liverpool le laboratoire nucléaire commun
Publicado: (1951)

Le premier super-cosmotron de trente milliards d'electrons-volts sera construit en Europe
por: Dauzats, C
Publicado: (1952)

Cannot write session to /tmp/vufind_sessions/sess_sq32d3n6h05rps1n4eji6k5sc7