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Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy

The timely diagnosis of Alzheimer’s disease (AD) and its prodromal stages is critically important for the patients, who manifest different neurodegenerative severity and progression risks, to take intervention and early symptomatic treatments before the brain damage is shaped. As one of the promisin...

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Autores principales: Ho, Thi Kieu Khanh, Kim, Minhee, Jeon, Younghun, Kim, Byeong C., Kim, Jae Gwan, Lee, Kun Ho, Song, Jong-In, Gwak, Jeonghwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087351/
https://www.ncbi.nlm.nih.gov/pubmed/35557842
http://dx.doi.org/10.3389/fnagi.2022.810125
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author Ho, Thi Kieu Khanh
Kim, Minhee
Jeon, Younghun
Kim, Byeong C.
Kim, Jae Gwan
Lee, Kun Ho
Song, Jong-In
Gwak, Jeonghwan
author_facet Ho, Thi Kieu Khanh
Kim, Minhee
Jeon, Younghun
Kim, Byeong C.
Kim, Jae Gwan
Lee, Kun Ho
Song, Jong-In
Gwak, Jeonghwan
author_sort Ho, Thi Kieu Khanh
collection PubMed
description The timely diagnosis of Alzheimer’s disease (AD) and its prodromal stages is critically important for the patients, who manifest different neurodegenerative severity and progression risks, to take intervention and early symptomatic treatments before the brain damage is shaped. As one of the promising techniques, functional near-infrared spectroscopy (fNIRS) has been widely employed to support early-stage AD diagnosis. This study aims to validate the capability of fNIRS coupled with Deep Learning (DL) models for AD multi-class classification. First, a comprehensive experimental design, including the resting, cognitive, memory, and verbal tasks was conducted. Second, to precisely evaluate the AD progression, we thoroughly examined the change of hemodynamic responses measured in the prefrontal cortex among four subject groups and among genders. Then, we adopted a set of DL architectures on an extremely imbalanced fNIRS dataset. The results indicated that the statistical difference between subject groups did exist during memory and verbal tasks. This presented the correlation of the level of hemoglobin activation and the degree of AD severity. There was also a gender effect on the hemoglobin changes due to the functional stimulation in our study. Moreover, we demonstrated the potential of distinguished DL models, which boosted the multi-class classification performance. The highest accuracy was achieved by Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM) using the original dataset of three hemoglobin types (0.909 ± 0.012 on average). Compared to conventional machine learning algorithms, DL models produced a better classification performance. These findings demonstrated the capability of DL frameworks on the imbalanced class distribution analysis and validated the great potential of fNIRS-based approaches to be further contributed to the development of AD diagnosis systems.
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spelling pubmed-90873512022-05-11 Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy Ho, Thi Kieu Khanh Kim, Minhee Jeon, Younghun Kim, Byeong C. Kim, Jae Gwan Lee, Kun Ho Song, Jong-In Gwak, Jeonghwan Front Aging Neurosci Aging Neuroscience The timely diagnosis of Alzheimer’s disease (AD) and its prodromal stages is critically important for the patients, who manifest different neurodegenerative severity and progression risks, to take intervention and early symptomatic treatments before the brain damage is shaped. As one of the promising techniques, functional near-infrared spectroscopy (fNIRS) has been widely employed to support early-stage AD diagnosis. This study aims to validate the capability of fNIRS coupled with Deep Learning (DL) models for AD multi-class classification. First, a comprehensive experimental design, including the resting, cognitive, memory, and verbal tasks was conducted. Second, to precisely evaluate the AD progression, we thoroughly examined the change of hemodynamic responses measured in the prefrontal cortex among four subject groups and among genders. Then, we adopted a set of DL architectures on an extremely imbalanced fNIRS dataset. The results indicated that the statistical difference between subject groups did exist during memory and verbal tasks. This presented the correlation of the level of hemoglobin activation and the degree of AD severity. There was also a gender effect on the hemoglobin changes due to the functional stimulation in our study. Moreover, we demonstrated the potential of distinguished DL models, which boosted the multi-class classification performance. The highest accuracy was achieved by Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM) using the original dataset of three hemoglobin types (0.909 ± 0.012 on average). Compared to conventional machine learning algorithms, DL models produced a better classification performance. These findings demonstrated the capability of DL frameworks on the imbalanced class distribution analysis and validated the great potential of fNIRS-based approaches to be further contributed to the development of AD diagnosis systems. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9087351/ /pubmed/35557842 http://dx.doi.org/10.3389/fnagi.2022.810125 Text en Copyright © 2022 Ho, Kim, Jeon, Kim, Kim, Lee, Song and Gwak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Ho, Thi Kieu Khanh
Kim, Minhee
Jeon, Younghun
Kim, Byeong C.
Kim, Jae Gwan
Lee, Kun Ho
Song, Jong-In
Gwak, Jeonghwan
Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title_full Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title_fullStr Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title_full_unstemmed Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title_short Deep Learning-Based Multilevel Classification of Alzheimer’s Disease Using Non-invasive Functional Near-Infrared Spectroscopy
title_sort deep learning-based multilevel classification of alzheimer’s disease using non-invasive functional near-infrared spectroscopy
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087351/
https://www.ncbi.nlm.nih.gov/pubmed/35557842
http://dx.doi.org/10.3389/fnagi.2022.810125
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