SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination

Little is known about the cellular immune response to SARS‐CoV‐2 vaccination in patients after HSCT and B‐NHL with iatrogenic B‐cell aplasia. In nonseroconverted HSCT patients, induction of specific T‐cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses...

Descripción completa

Detalles Bibliográficos
Autores principales: Jarisch, Andrea, Wiercinska, Eliza, Daqiq‐Mirdad, Shabnam, Hellstern, Helen, Ajib, Salem, Cremer, Anjali, Nguyen, Ngoc Thien Thu, Dukat, Alexandra, Ullrich, Evelyn, Ciesek, Sandra, Chow, Kai‐Uwe, Serve, Hubert, Seifried, Erhard, Bader, Peter, Bonig, Halvard, Bug, Gesine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Notes and Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087431/
https://www.ncbi.nlm.nih.gov/pubmed/35389515
http://dx.doi.org/10.1002/eji.202149771
_version_ 1784704195511713792
author Jarisch, Andrea
Wiercinska, Eliza
Daqiq‐Mirdad, Shabnam
Hellstern, Helen
Ajib, Salem
Cremer, Anjali
Nguyen, Ngoc Thien Thu
Dukat, Alexandra
Ullrich, Evelyn
Ciesek, Sandra
Chow, Kai‐Uwe
Serve, Hubert
Seifried, Erhard
Bader, Peter
Bonig, Halvard
Bug, Gesine
author_facet Jarisch, Andrea
Wiercinska, Eliza
Daqiq‐Mirdad, Shabnam
Hellstern, Helen
Ajib, Salem
Cremer, Anjali
Nguyen, Ngoc Thien Thu
Dukat, Alexandra
Ullrich, Evelyn
Ciesek, Sandra
Chow, Kai‐Uwe
Serve, Hubert
Seifried, Erhard
Bader, Peter
Bonig, Halvard
Bug, Gesine
author_sort Jarisch, Andrea
collection PubMed
description Little is known about the cellular immune response to SARS‐CoV‐2 vaccination in patients after HSCT and B‐NHL with iatrogenic B‐cell aplasia. In nonseroconverted HSCT patients, induction of specific T‐cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen‐specific T‐cell responses. [Image: see text]
format Online
Article
Text
id pubmed-9087431
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90874312022-05-10 SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination Jarisch, Andrea Wiercinska, Eliza Daqiq‐Mirdad, Shabnam Hellstern, Helen Ajib, Salem Cremer, Anjali Nguyen, Ngoc Thien Thu Dukat, Alexandra Ullrich, Evelyn Ciesek, Sandra Chow, Kai‐Uwe Serve, Hubert Seifried, Erhard Bader, Peter Bonig, Halvard Bug, Gesine Eur J Immunol Notes and Insights Little is known about the cellular immune response to SARS‐CoV‐2 vaccination in patients after HSCT and B‐NHL with iatrogenic B‐cell aplasia. In nonseroconverted HSCT patients, induction of specific T‐cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen‐specific T‐cell responses. [Image: see text] John Wiley and Sons Inc. 2022-04-28 2022-07 /pmc/articles/PMC9087431/ /pubmed/35389515 http://dx.doi.org/10.1002/eji.202149771 Text en © 2022 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Notes and Insights
Jarisch, Andrea
Wiercinska, Eliza
Daqiq‐Mirdad, Shabnam
Hellstern, Helen
Ajib, Salem
Cremer, Anjali
Nguyen, Ngoc Thien Thu
Dukat, Alexandra
Ullrich, Evelyn
Ciesek, Sandra
Chow, Kai‐Uwe
Serve, Hubert
Seifried, Erhard
Bader, Peter
Bonig, Halvard
Bug, Gesine
SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title_full SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title_fullStr SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title_full_unstemmed SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title_short SARS‐CoV‐2‐specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID‐19 vaccination
title_sort sars‐cov‐2‐specific t cells are generated in less than half of allogeneic hsct recipients failing to seroconvert after covid‐19 vaccination
topic Notes and Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087431/
https://www.ncbi.nlm.nih.gov/pubmed/35389515
http://dx.doi.org/10.1002/eji.202149771
work_keys_str_mv AT jarischandrea sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT wiercinskaeliza sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT daqiqmirdadshabnam sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT hellsternhelen sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT ajibsalem sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT cremeranjali sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT nguyenngocthienthu sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT dukatalexandra sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT ullrichevelyn sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT cieseksandra sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT chowkaiuwe sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT servehubert sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT seifriederhard sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT baderpeter sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT bonighalvard sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination
AT buggesine sarscov2specifictcellsaregeneratedinlessthanhalfofallogeneichsctrecipientsfailingtoseroconvertaftercovid19vaccination

Ejemplares similares