Cargando…
Theoretical study of mechanisms for the hydrolytic deamination of cytosine via steered molecular dynamic simulations
Gibbs free energy profiles of the cytosine deamination assisted by a water molecule in a discrete aqueous medium were obtained by the application of Steered Molecular Dynamic (SMD) simulations. Two pathways were considered to explain the mechanism of this process, where the water molecule attacks th...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087476/ https://www.ncbi.nlm.nih.gov/pubmed/35547048 http://dx.doi.org/10.1039/c8ra07390b |