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Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects

The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid are expected to be associated with many health benefits, but little is known on the pharmacokinetics and metabolism. The aim of this study is to confirm the metabolism and pharmacokinetics of RJ fatty...

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Autores principales: Yamaga, Masayuki, Tani, Hiroko, Yamaki, Ayanori, Tatefuji, Tomoki, Hashimoto, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087820/
https://www.ncbi.nlm.nih.gov/pubmed/35548266
http://dx.doi.org/10.1039/c9ra02991e
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author Yamaga, Masayuki
Tani, Hiroko
Yamaki, Ayanori
Tatefuji, Tomoki
Hashimoto, Ken
author_facet Yamaga, Masayuki
Tani, Hiroko
Yamaki, Ayanori
Tatefuji, Tomoki
Hashimoto, Ken
author_sort Yamaga, Masayuki
collection PubMed
description The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid are expected to be associated with many health benefits, but little is known on the pharmacokinetics and metabolism. The aim of this study is to confirm the metabolism and pharmacokinetics of RJ fatty acids in humans. Twelve volunteers received RJ capsules or enzyme treated RJ (ETRJ) capsules (800 mg). The other group received two doses of ETRJ tablets (800 mg and 1600 mg). Plasma samples were collected up to 12 h after the RJ intake and urine samples were collected within 24 h after ETRJ tablet consumption. The samples were analyzed by LC/MS/MS. A multivariate analysis of the RJ dose plasma samples detected 2-decenedioic acid (2-DA), sebacic acid (SA), and 3-hydroxysebacic acid (3-HSA) with significantly different intensities (P < 0.05) before and after RJ intake. The area under the concentration (AUC) of 2-DA, SA, and 3-HSA was 2500.05 ± 569.58, 322.57 ± 137.36, and 242.98 ± 58.36 ng h mL(−1), respectively. By enzyme treatment, the AUC of 2-DA, SA, and 3-HSA was significantly increased (P < 0.05). The values of AUC and urinary excretion of these metabolites were dose-dependent. The major RJ fatty acids were metabolized to dicarboxylate, absorbed into the circulation and their absorption increased by enzyme treatment. This study provides useful information that will support studies aimed at clarifying the identity of bioactive RJ constituents and their biological effect, and further the development of RJ.
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spelling pubmed-90878202022-05-10 Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects Yamaga, Masayuki Tani, Hiroko Yamaki, Ayanori Tatefuji, Tomoki Hashimoto, Ken RSC Adv Chemistry The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid are expected to be associated with many health benefits, but little is known on the pharmacokinetics and metabolism. The aim of this study is to confirm the metabolism and pharmacokinetics of RJ fatty acids in humans. Twelve volunteers received RJ capsules or enzyme treated RJ (ETRJ) capsules (800 mg). The other group received two doses of ETRJ tablets (800 mg and 1600 mg). Plasma samples were collected up to 12 h after the RJ intake and urine samples were collected within 24 h after ETRJ tablet consumption. The samples were analyzed by LC/MS/MS. A multivariate analysis of the RJ dose plasma samples detected 2-decenedioic acid (2-DA), sebacic acid (SA), and 3-hydroxysebacic acid (3-HSA) with significantly different intensities (P < 0.05) before and after RJ intake. The area under the concentration (AUC) of 2-DA, SA, and 3-HSA was 2500.05 ± 569.58, 322.57 ± 137.36, and 242.98 ± 58.36 ng h mL(−1), respectively. By enzyme treatment, the AUC of 2-DA, SA, and 3-HSA was significantly increased (P < 0.05). The values of AUC and urinary excretion of these metabolites were dose-dependent. The major RJ fatty acids were metabolized to dicarboxylate, absorbed into the circulation and their absorption increased by enzyme treatment. This study provides useful information that will support studies aimed at clarifying the identity of bioactive RJ constituents and their biological effect, and further the development of RJ. The Royal Society of Chemistry 2019-05-17 /pmc/articles/PMC9087820/ /pubmed/35548266 http://dx.doi.org/10.1039/c9ra02991e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yamaga, Masayuki
Tani, Hiroko
Yamaki, Ayanori
Tatefuji, Tomoki
Hashimoto, Ken
Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title_full Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title_fullStr Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title_full_unstemmed Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title_short Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
title_sort metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087820/
https://www.ncbi.nlm.nih.gov/pubmed/35548266
http://dx.doi.org/10.1039/c9ra02991e
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